FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229368537> ?p ?o ?g. }

• W4229368537 endingPage "3011" @default.
• W4229368537 startingPage "3011" @default.
• W4229368537 abstract "Iron is a crucial element required for the proper functioning of the body. For instance, hemoglobin is the vital component in the blood that delivers oxygen to various parts of the body. The heme protein present in hemoglobin comprises iron in the form of a ferrous state which regulates oxygen delivery. Excess iron in the body is stored as ferritin and would be utilized under iron-deficient conditions. Surprisingly, cancer cells as well as cancer stem cells have elevated ferritin levels suggesting that iron plays a vital role in protecting these cells. However, apart from the cytoprotective role iron also has the potential to induce cell death via ferroptosis which is a non-apoptotic cell death dependent on iron reserves. Apoptosis a caspase-dependent cell death mechanism is effective on cancer cells however little is known about its impact on cancer stem cell death. This paper focuses on the molecular characteristics of apoptosis and ferroptosis and the importance of switching to ferroptosis to target cancer stem cells death thereby preventing cancer relapse. To the best of our knowledge, this is the first review to demonstrate the importance of intracellular iron in regulating the switching of tumor cells and therapy resistant CSCs from apoptosis to ferroptosis." @default.
• W4229368537 created "2022-05-10" @default.
• W4229368537 creator A5014897747 @default.
• W4229368537 creator A5022210372 @default.
• W4229368537 creator A5039850083 @default.
• W4229368537 creator A5041956409 @default.
• W4229368537 creator A5043429891 @default.
• W4229368537 creator A5052881336 @default.
• W4229368537 creator A5062409003 @default.
• W4229368537 creator A5063891232 @default.
• W4229368537 creator A5087169766 @default.
• W4229368537 date "2022-05-07" @default.
• W4229368537 modified "2023-10-15" @default.
• W4229368537 title "Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells" @default.
• W4229368537 cites W1009211540 @default.
• W4229368537 cites W1545715882 @default.
• W4229368537 cites W1768951556 @default.
• W4229368537 cites W1845459216 @default.
• W4229368537 cites W1965618865 @default.
• W4229368537 cites W1972288692 @default.
• W4229368537 cites W1974270860 @default.
• W4229368537 cites W1976690209 @default.
• W4229368537 cites W1977071644 @default.
• W4229368537 cites W1994718022 @default.
• W4229368537 cites W1997316363 @default.
• W4229368537 cites W1998175001 @default.
• W4229368537 cites W2002490399 @default.
• W4229368537 cites W2008693250 @default.
• W4229368537 cites W2008757142 @default.
• W4229368537 cites W2014128254 @default.
• W4229368537 cites W2017975901 @default.
• W4229368537 cites W2020932850 @default.
• W4229368537 cites W2028343479 @default.
• W4229368537 cites W2033286301 @default.
• W4229368537 cites W2038572183 @default.
• W4229368537 cites W2041399911 @default.
• W4229368537 cites W2042591570 @default.
• W4229368537 cites W2062069198 @default.
• W4229368537 cites W2062107099 @default.
• W4229368537 cites W2069267879 @default.
• W4229368537 cites W2100388370 @default.
• W4229368537 cites W2107704801 @default.
• W4229368537 cites W2123216084 @default.
• W4229368537 cites W2123627500 @default.
• W4229368537 cites W2143916432 @default.
• W4229368537 cites W2156644257 @default.
• W4229368537 cites W2161103689 @default.
• W4229368537 cites W2163002030 @default.
• W4229368537 cites W2167414381 @default.
• W4229368537 cites W2169984828 @default.
• W4229368537 cites W2258749495 @default.
• W4229368537 cites W2346455216 @default.
• W4229368537 cites W2417426823 @default.
• W4229368537 cites W2465250101 @default.
• W4229368537 cites W2478124038 @default.
• W4229368537 cites W2488521558 @default.
• W4229368537 cites W2508296626 @default.
• W4229368537 cites W2518357275 @default.
• W4229368537 cites W2549188196 @default.
• W4229368537 cites W2552793060 @default.
• W4229368537 cites W2554956457 @default.
• W4229368537 cites W2604049161 @default.
• W4229368537 cites W2624576378 @default.
• W4229368537 cites W2762087180 @default.
• W4229368537 cites W2763367287 @default.
• W4229368537 cites W2766270233 @default.
• W4229368537 cites W2775036989 @default.
• W4229368537 cites W2778627538 @default.
• W4229368537 cites W2791261365 @default.
• W4229368537 cites W2806713886 @default.
• W4229368537 cites W2809263305 @default.
• W4229368537 cites W2809820903 @default.
• W4229368537 cites W2833129054 @default.
• W4229368537 cites W2884543518 @default.
• W4229368537 cites W2886984390 @default.
• W4229368537 cites W2894453209 @default.
• W4229368537 cites W2898371604 @default.
• W4229368537 cites W2899828045 @default.
• W4229368537 cites W2900771119 @default.
• W4229368537 cites W2901573161 @default.
• W4229368537 cites W2902857503 @default.
• W4229368537 cites W2907110005 @default.
• W4229368537 cites W2945161487 @default.
• W4229368537 cites W2953434773 @default.
• W4229368537 cites W2954933005 @default.
• W4229368537 cites W2969290849 @default.
• W4229368537 cites W2975105312 @default.
• W4229368537 cites W2998463707 @default.
• W4229368537 cites W2999044683 @default.
• W4229368537 cites W3015020891 @default.
• W4229368537 cites W3016288444 @default.
• W4229368537 cites W3032185138 @default.
• W4229368537 cites W3038887094 @default.
• W4229368537 cites W3083112620 @default.
• W4229368537 cites W3090693089 @default.
• W4229368537 cites W3103771844 @default.
• W4229368537 cites W3110165959 @default.
• W4229368537 cites W3123600031 @default.

• next