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- W4229372415 abstract "<b>Background:</b> About 10% of patients develop persistent symptoms after mild/moderate COVID-19. We have previously reported detection of antinuclear autoantibodies/extractable nuclear antigens (ANA/ENA) in patients with severe COVID-19. <b>Objectives:</b> The aim of this small pilot study was to characterize long-/post-COVID and to evaluate possible similarities between lung involvement in long-/post-COVID and connective tissue disease (CTD). <b>Methods:</b> We prospectively enrolled 70 previously healthy patients with persistent pulmonal symptoms after mild/ moderate COVID-19 without hospitalization. We performed clinical evaluation including pulmonary function tests, computed tomography (CT) and serology for ANA/ENA. In all patients, transbronchial biopsies (TBBs) were taken for histopathological assessment. <b>Results:</b> Most patients presented with reduced lung-recruitment reserves in spiroergometry and slight lymphocytosis in bronchoalveolar lavage (BAL) fluid. CT pattern showed bronchial wall thickening, dilated peripheral pulmonary vessels and enhanced low-attenuation volume. Histopathological assessment showed interstitial lymphocytosis with alveolar fibrin and organizing pneumonia. Ultrastructural analyses revealed interstitial collagen deposition. <b>Conclusion:</b> While histopathology of pulmonary long-/post-COVID alone is unspecific, the combination with clinical and radiological features together with detection of autoantibodies would allow for a diagnosis of “interstitial pneumonia with autoimmune features” (IPAF). This results in a targeted treatment approach." @default.
- W4229372415 created "2022-05-10" @default.
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- W4229372415 date "2022-03-10" @default.
- W4229372415 modified "2023-10-14" @default.
- W4229372415 title "Post-COVID: The multimodal path to the right treatment strategy" @default.
- W4229372415 doi "https://doi.org/10.1183/23120541.lsc-2022.80" @default.
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