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- W4229373956 endingPage "5924" @default.
- W4229373956 startingPage "5903" @default.
- W4229373956 abstract "There is a wide variety of neurodegenerative diseases, among which frontotemporal dementia stands out. These are the second most frequent cause of dementia in the world and demand the search for an effective treatment. This disease is linked to the abnormal behavior of proteins, which group together to form insoluble aggregates. It has been shown that the tau protein and TDP-43 are the main proteins involved in these pathologies. This article details 11 compounds already used in different neuropathologies, which may serve as potential drugs against these proteins. The mechanism of how most of these molecules inhibited the tau and TDP-43 aggregation process was highlighted. Importantly, Curcumin, Proanthocyanidin B2, Oleocanthal, Oleuropein Aglycone, Thionine, and Resveratrol had been reported as direct inhibitors of tau. While 4-aminoquinoline, Dimethoxycurcumin, and Auranofin directly inhibited TDP-43. Epigallocatechin- 3- gallate and Methylene Blue were described as tau and TDP-43 inhibitors. In this review, it is proposed that future research could elucidate the detailed inhibition mechanisms of these compounds to obtain relevant data to advance in treatments search for these coexisting proteins in frontotemporal dementia." @default.
- W4229373956 created "2022-05-10" @default.
- W4229373956 creator A5017514330 @default.
- W4229373956 creator A5033293449 @default.
- W4229373956 creator A5040175040 @default.
- W4229373956 creator A5046183103 @default.
- W4229373956 creator A5087668748 @default.
- W4229373956 date "2022-11-01" @default.
- W4229373956 modified "2023-10-01" @default.
- W4229373956 title "Bringing the Spotlight to Tau and TDP-43 in Frontotemporal Dementia: A Review of Promising Chemical Compounds" @default.
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