Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229374443> ?p ?o ?g. }
- W4229374443 abstract "Several neurological diseases share pathological alterations, even though they differ in their etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress, mitochondrial dysfunction and amyloidosis are biological events found in those neurological disorders. Altered insulin-mediated signaling and brain glucose hypometabolism are characteristic signs observed in the brains of patients with certain neurological diseases, but also others such as type 2 diabetes mellitus and vascular diseases. Thus, significant reductions in insulin receptor autophosphorylation and Akt kinase activity, and increased GSK-3 activity and insulin resistance, have been reported in these neurological diseases as contributing to the decline in cognitive function. Supporting this relationship is the fact that nasal and hippocampal insulin administration has been found to improve cognitive function. Additionally, brain glucose hypometabolism precedes the unmistakable clinical manifestations of some of these diseases by years, which may become a useful early biomarker. Deficiencies in the major pathways of oxidative energy metabolism have been reported in patients with several of these neurological diseases, which supports the hypothesis of their metabolic background. This review remarks on the significance of insulin and brain glucose metabolism alterations as keystone common pathogenic substrates for certain neurological diseases, highlighting new potential targets." @default.
- W4229374443 created "2022-05-10" @default.
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- W4229374443 date "2022-05-09" @default.
- W4229374443 modified "2023-10-16" @default.
- W4229374443 title "Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases" @default.
- W4229374443 cites W1499787223 @default.
- W4229374443 cites W1513719789 @default.
- W4229374443 cites W152417155 @default.
- W4229374443 cites W1524321743 @default.
- W4229374443 cites W1543788907 @default.
- W4229374443 cites W1551543102 @default.
- W4229374443 cites W1553669285 @default.
- W4229374443 cites W1565096249 @default.
- W4229374443 cites W157140528 @default.
- W4229374443 cites W157501186 @default.
- W4229374443 cites W1586231797 @default.
- W4229374443 cites W1590034801 @default.
- W4229374443 cites W1637823276 @default.
- W4229374443 cites W16691718 @default.
- W4229374443 cites W1674464860 @default.
- W4229374443 cites W1689835701 @default.
- W4229374443 cites W1712017471 @default.
- W4229374443 cites W1797578063 @default.
- W4229374443 cites W1847812830 @default.
- W4229374443 cites W1896225205 @default.
- W4229374443 cites W1923800470 @default.
- W4229374443 cites W1927053140 @default.
- W4229374443 cites W1945791651 @default.
- W4229374443 cites W1960145271 @default.
- W4229374443 cites W1962641016 @default.
- W4229374443 cites W1964661125 @default.
- W4229374443 cites W1964893196 @default.
- W4229374443 cites W1968530575 @default.
- W4229374443 cites W1971911315 @default.
- W4229374443 cites W1974194082 @default.
- W4229374443 cites W1976072714 @default.
- W4229374443 cites W1982479748 @default.
- W4229374443 cites W1982795519 @default.
- W4229374443 cites W1984553976 @default.
- W4229374443 cites W1986788285 @default.
- W4229374443 cites W1988730230 @default.
- W4229374443 cites W1988873133 @default.
- W4229374443 cites W1989407221 @default.
- W4229374443 cites W1990293508 @default.
- W4229374443 cites W1993237799 @default.
- W4229374443 cites W1993642953 @default.
- W4229374443 cites W1994326835 @default.
- W4229374443 cites W1995762768 @default.
- W4229374443 cites W1998620161 @default.
- W4229374443 cites W2002444111 @default.
- W4229374443 cites W2004325493 @default.
- W4229374443 cites W2004653921 @default.
- W4229374443 cites W2004856335 @default.
- W4229374443 cites W2005466794 @default.
- W4229374443 cites W2007026767 @default.
- W4229374443 cites W2007118678 @default.
- W4229374443 cites W2008685237 @default.
- W4229374443 cites W2009064331 @default.
- W4229374443 cites W2010464096 @default.
- W4229374443 cites W2011637489 @default.
- W4229374443 cites W2011829284 @default.
- W4229374443 cites W2015163544 @default.
- W4229374443 cites W2015472023 @default.
- W4229374443 cites W2015867840 @default.
- W4229374443 cites W2016721233 @default.
- W4229374443 cites W2023136593 @default.
- W4229374443 cites W2023604436 @default.
- W4229374443 cites W2025725983 @default.
- W4229374443 cites W2027250745 @default.
- W4229374443 cites W2027376281 @default.
- W4229374443 cites W2028502361 @default.
- W4229374443 cites W2030270894 @default.
- W4229374443 cites W2030868611 @default.
- W4229374443 cites W2031155126 @default.
- W4229374443 cites W2032885546 @default.
- W4229374443 cites W2032920422 @default.
- W4229374443 cites W2032998415 @default.
- W4229374443 cites W2033411034 @default.
- W4229374443 cites W2034688612 @default.
- W4229374443 cites W2036755018 @default.
- W4229374443 cites W2039022835 @default.
- W4229374443 cites W2041066331 @default.
- W4229374443 cites W2041102868 @default.
- W4229374443 cites W2042600060 @default.
- W4229374443 cites W2045014938 @default.
- W4229374443 cites W2046898049 @default.
- W4229374443 cites W2047662727 @default.
- W4229374443 cites W2049871798 @default.
- W4229374443 cites W2050702457 @default.
- W4229374443 cites W2051361265 @default.
- W4229374443 cites W2052859130 @default.