Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229441796> ?p ?o ?g. }
- W4229441796 endingPage "104047" @default.
- W4229441796 startingPage "104047" @default.
- W4229441796 abstract "BackgroundType I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous in females than in males. Whether this sex bias persists in ageing people is currently unknown. In this study, we investigated the effect of sex and aging on IFN-α production induced by PRR agonist ligands.MethodsIn a large cohort of individuals from 19 to 97 years old, we measured the production of IFN-α and inflammatory cytokines in whole-blood upon stimulation with either R-848, ODN M362 CpG-C, or cGAMP, which activate the TLR7/8, TLR9 or STING pathways, respectively. We further characterized the cellular sources of IFN-α.FindingsWe observed a female predominance in IFN-α production by pDCs in response to TLR7 or TLR9 ligands. The higher TLR7-driven IFN-α production in females was robustly maintained across ages, including the elderly. The sex-bias in TLR9-driven interferon production was lost after age 60, which correlated with the decline in circulating pDCs. By contrast, STING-driven IFN-α production was similar in both sexes, preserved with aging, and correlated with circulating monocyte numbers. Indeed, monocytes were the primary cellular source of IFN-α in response to cGAMP.InterpretationWe show that the sex bias in the TLR7-induced IFN-I production is strongly maintained through ages, and identify monocytes as the main source of IFN-I production via STING pathway.FundingThis work was supported by grants from Région Occitanie/Pyrénées-Méditerranée (#12052910, Inspire Program #1901175), University Paul Sabatier, and the European Regional Development Fund (MP0022856)." @default.
- W4229441796 created "2022-05-11" @default.
- W4229441796 creator A5001018926 @default.
- W4229441796 creator A5005440680 @default.
- W4229441796 creator A5008440808 @default.
- W4229441796 creator A5011699827 @default.
- W4229441796 creator A5013483692 @default.
- W4229441796 creator A5024002205 @default.
- W4229441796 creator A5046269050 @default.
- W4229441796 creator A5059965844 @default.
- W4229441796 creator A5072324110 @default.
- W4229441796 creator A5086040203 @default.
- W4229441796 creator A5089609857 @default.
- W4229441796 creator A5090535752 @default.
- W4229441796 creator A5091610468 @default.
- W4229441796 date "2022-06-01" @default.
- W4229441796 modified "2023-10-15" @default.
- W4229441796 title "Monocytes are the main source of STING-mediated IFN-α production" @default.
- W4229441796 cites W1772394217 @default.
- W4229441796 cites W1828298093 @default.
- W4229441796 cites W1966694479 @default.
- W4229441796 cites W1968536379 @default.
- W4229441796 cites W1971997924 @default.
- W4229441796 cites W1984830992 @default.
- W4229441796 cites W1985071582 @default.
- W4229441796 cites W1986315531 @default.
- W4229441796 cites W1993658270 @default.
- W4229441796 cites W2004887151 @default.
- W4229441796 cites W2027349186 @default.
- W4229441796 cites W2027798298 @default.
- W4229441796 cites W2028917545 @default.
- W4229441796 cites W2052586618 @default.
- W4229441796 cites W2058649253 @default.
- W4229441796 cites W2061480204 @default.
- W4229441796 cites W2063855257 @default.
- W4229441796 cites W2074963908 @default.
- W4229441796 cites W2076092191 @default.
- W4229441796 cites W2091790511 @default.
- W4229441796 cites W2135660738 @default.
- W4229441796 cites W2145270463 @default.
- W4229441796 cites W2145622818 @default.
- W4229441796 cites W2151777859 @default.
- W4229441796 cites W2173859862 @default.
- W4229441796 cites W2285065014 @default.
- W4229441796 cites W2518536270 @default.
- W4229441796 cites W2556766135 @default.
- W4229441796 cites W2586076086 @default.
- W4229441796 cites W2587763458 @default.
- W4229441796 cites W2630573111 @default.
- W4229441796 cites W2747568591 @default.
- W4229441796 cites W2757389584 @default.
- W4229441796 cites W2783608729 @default.
- W4229441796 cites W2785308950 @default.
- W4229441796 cites W2789889936 @default.
- W4229441796 cites W2795875233 @default.
- W4229441796 cites W2804737546 @default.
- W4229441796 cites W2885999695 @default.
- W4229441796 cites W2894783114 @default.
- W4229441796 cites W2906587554 @default.
- W4229441796 cites W2908943028 @default.
- W4229441796 cites W2921875691 @default.
- W4229441796 cites W2926877280 @default.
- W4229441796 cites W2931094336 @default.
- W4229441796 cites W2936804536 @default.
- W4229441796 cites W2943419837 @default.
- W4229441796 cites W2945740253 @default.
- W4229441796 cites W2963643883 @default.
- W4229441796 cites W2984299508 @default.
- W4229441796 cites W3004442407 @default.
- W4229441796 cites W3030603206 @default.
- W4229441796 cites W3035353028 @default.
- W4229441796 cites W3036374348 @default.
- W4229441796 cites W3100860354 @default.
- W4229441796 cites W3110738325 @default.
- W4229441796 cites W3110901620 @default.
- W4229441796 cites W3168435443 @default.
- W4229441796 doi "https://doi.org/10.1016/j.ebiom.2022.104047" @default.
- W4229441796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35561451" @default.
- W4229441796 hasPublicationYear "2022" @default.
- W4229441796 type Work @default.
- W4229441796 citedByCount "6" @default.
- W4229441796 countsByYear W42294417962022 @default.
- W4229441796 countsByYear W42294417962023 @default.
- W4229441796 crossrefType "journal-article" @default.
- W4229441796 hasAuthorship W4229441796A5001018926 @default.
- W4229441796 hasAuthorship W4229441796A5005440680 @default.
- W4229441796 hasAuthorship W4229441796A5008440808 @default.
- W4229441796 hasAuthorship W4229441796A5011699827 @default.
- W4229441796 hasAuthorship W4229441796A5013483692 @default.
- W4229441796 hasAuthorship W4229441796A5024002205 @default.
- W4229441796 hasAuthorship W4229441796A5046269050 @default.
- W4229441796 hasAuthorship W4229441796A5059965844 @default.
- W4229441796 hasAuthorship W4229441796A5072324110 @default.
- W4229441796 hasAuthorship W4229441796A5086040203 @default.
- W4229441796 hasAuthorship W4229441796A5089609857 @default.
- W4229441796 hasAuthorship W4229441796A5090535752 @default.
- W4229441796 hasAuthorship W4229441796A5091610468 @default.
- W4229441796 hasBestOaLocation W42294417961 @default.