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- W4229442166 abstract "Germline mutations in BRCA1 or BRCA2 exist in ~2-7% of breast cancer patients, which has led to the approval of PARP inhibitors in the advanced setting. We have previously reported a phase II neoadjuvant trial of single agent talazoparib for patients with germline BRCA pathogenic variants with a pathologic complete response (pCR) rate of 53%. As nearly half of the patients treated did not have pCR, better strategies are needed to overcome treatment resistance. To this end, we conducted multi-omic analysis of 13 treatment naïve breast cancer tumors from patients that went on to receive single-agent neoadjuvant talazoparib. We looked for biomarkers that were predictive of response (assessed by residual cancer burden) after 6 months of therapy. We found that all resistant tumors exhibited either the loss of SHLD2, expression of a hypoxia signature, or expression of a stem cell signature. These results indicate that the deep analysis of pre-treatment tumors can identify biomarkers that are predictive of response to talazoparib and potentially other PARP inhibitors, and provides a framework that will allow for better selection of patients for treatment, as well as a roadmap for the development of novel combination therapies to prevent emergence of resistance." @default.
- W4229442166 created "2022-05-11" @default.
- W4229442166 creator A5004242684 @default.
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- W4229442166 creator A5084233435 @default.
- W4229442166 date "2022-05-10" @default.
- W4229442166 modified "2023-10-14" @default.
- W4229442166 title "Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers" @default.
- W4229442166 cites W1250565189 @default.
- W4229442166 cites W1563940013 @default.
- W4229442166 cites W1640635403 @default.
- W4229442166 cites W1775309324 @default.
- W4229442166 cites W1781764024 @default.
- W4229442166 cites W1855992024 @default.
- W4229442166 cites W1898580708 @default.
- W4229442166 cites W1965009601 @default.
- W4229442166 cites W1971950332 @default.
- W4229442166 cites W1973268287 @default.
- W4229442166 cites W1984068087 @default.
- W4229442166 cites W1996118868 @default.
- W4229442166 cites W2010457001 @default.
- W4229442166 cites W2017171454 @default.
- W4229442166 cites W2041381844 @default.
- W4229442166 cites W2041399489 @default.
- W4229442166 cites W2047992261 @default.
- W4229442166 cites W2048366300 @default.
- W4229442166 cites W2067117419 @default.
- W4229442166 cites W2072709416 @default.
- W4229442166 cites W2073569331 @default.
- W4229442166 cites W2084116712 @default.
- W4229442166 cites W2084833108 @default.
- W4229442166 cites W2087367170 @default.
- W4229442166 cites W2088875346 @default.
- W4229442166 cites W2089454614 @default.
- W4229442166 cites W2094475133 @default.
- W4229442166 cites W2096145980 @default.
- W4229442166 cites W2096276671 @default.
- W4229442166 cites W2096741239 @default.
- W4229442166 cites W2096766502 @default.
- W4229442166 cites W2098503539 @default.
- W4229442166 cites W2102298903 @default.
- W4229442166 cites W2103441770 @default.
- W4229442166 cites W2106578986 @default.
- W4229442166 cites W2110137106 @default.
- W4229442166 cites W2114381883 @default.
- W4229442166 cites W2114787582 @default.
- W4229442166 cites W2119180969 @default.
- W4229442166 cites W2119741718 @default.
- W4229442166 cites W2124470568 @default.
- W4229442166 cites W2131271579 @default.
- W4229442166 cites W2132174822 @default.
- W4229442166 cites W2134151441 @default.
- W4229442166 cites W2134526812 @default.
- W4229442166 cites W2134735385 @default.
- W4229442166 cites W2138601221 @default.
- W4229442166 cites W2143238378 @default.
- W4229442166 cites W2147629880 @default.
- W4229442166 cites W2149332737 @default.
- W4229442166 cites W2150111967 @default.
- W4229442166 cites W2151509048 @default.
- W4229442166 cites W2151794156 @default.
- W4229442166 cites W2152061559 @default.
- W4229442166 cites W2164670057 @default.
- W4229442166 cites W2168133698 @default.
- W4229442166 cites W2168409298 @default.
- W4229442166 cites W2169456326 @default.
- W4229442166 cites W2170490448 @default.
- W4229442166 cites W2170943405 @default.
- W4229442166 cites W2171892226 @default.
- W4229442166 cites W2179438025 @default.
- W4229442166 cites W2235737683 @default.
- W4229442166 cites W2276335691 @default.
- W4229442166 cites W2318567174 @default.
- W4229442166 cites W2343436177 @default.
- W4229442166 cites W2405513305 @default.
- W4229442166 cites W2417483443 @default.
- W4229442166 cites W2472306545 @default.
- W4229442166 cites W2476568892 @default.
- W4229442166 cites W2513185582 @default.
- W4229442166 cites W2569734059 @default.
- W4229442166 cites W2588635345 @default.
- W4229442166 cites W2589334089 @default.
- W4229442166 cites W2605525619 @default.
- W4229442166 cites W2606001457 @default.
- W4229442166 cites W2608211931 @default.
- W4229442166 cites W2621271973 @default.
- W4229442166 cites W2622573148 @default.
- W4229442166 cites W2623263876 @default.
- W4229442166 cites W2684097212 @default.
- W4229442166 cites W2741214285 @default.
- W4229442166 cites W2748606465 @default.
- W4229442166 cites W2749641460 @default.
- W4229442166 cites W2766266723 @default.
- W4229442166 cites W2767593721 @default.
- W4229442166 cites W2769003179 @default.
- W4229442166 cites W2795708528 @default.
- W4229442166 cites W2798183676 @default.