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• W4229447908 endingPage "2336" @default.
• W4229447908 startingPage "2336" @default.
• W4229447908 abstract "Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor interactions with Ephrin ligands lead to bidirectional signals in the recipient and effector cells. The consequences of continuous reverse Ephrin signaling activation in fibroblasts on prostate cancer (PCa) is unknown. When compared to benign prostate fibroblast, CAF displayed higher expression of Ephrin B1, B2, and B3 ligands (EFNB1, EFNB2, and EFNB3). In this study, we found that continuous activation of EFNB1 and EFNB3 in a benign human prostate stromal cell line (BHPrS1) increased the expression of CAF markers and induced a CAF phenotype. BHPrS1EFNB1 and BHPrS1EFNB3 displayed a pro-tumorigenic secretome with multiple effects on neovascularization, collagen deposition, and cancer cell proliferation, overall increasing tumorigenicity of a premalignant prostate epithelial cell line BPH1 and PCa cell line LNCaP, both in vitro and in vivo. Inhibition of Src family kinases (SFK) in BHPrS1EFNB1 and BHPrS1EFNB3 suppressed EFNB-induced ɑ-SMA (Alpha-smooth muscle actin) and TN-C (Tenascin-C) in vitro. Our study suggests that acquisition of CAF characteristics via SFK activation in response to increased EFNB ligands could promote carcinogenesis via modulation of TME in PCa." @default.
• W4229447908 created "2022-05-11" @default.
• W4229447908 creator A5005453423 @default.
• W4229447908 creator A5075406798 @default.
• W4229447908 creator A5090559554 @default.
• W4229447908 date "2022-05-09" @default.
• W4229447908 modified "2023-10-09" @default.
• W4229447908 title "Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer" @default.
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• W4229447908 doi "https://doi.org/10.3390/cancers14092336" @default.
• W4229447908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35565468" @default.
• W4229447908 hasPublicationYear "2022" @default.
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