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- W4229449712 abstract "Quantum dots (QDs) are a class of semiconductor nanocrystal used broadly as fluorescent emitters for analytical studies in the life sciences. These nanomaterials are particularly valuable for single-particle imaging and tracking applications in cells and tissues. An ongoing technological goal is to reduce the hydrodynamic size of QDs to enhance access to sterically hindered biological targets. Multidentate polymer coatings are a focus of these efforts and have resulted in compact and stable QDs with hydrodynamic diameters near 10 nm. New developments are needed to reach smaller sizes to further enhance transport through pores in cells and tissues. Here, we describe how structural characteristics of linear multidentate copolymers determine hydrodynamic size, colloidal stability, and biomolecular interactions of coated QDs. We tune copolymer composition, degree of polymerization, and hydrophilic group length, and coat polymers on CdSe and (core)shell (HgCdSe)CdZnS QDs. We find that a broad range of polymer structures and compositions yield stable colloidal dispersions; however, hydrodynamic size minimization and nonspecific binding resistance can only be simultaneously achieved within a narrow range of properties, requiring short polymers, balanced compositions, and small nanocrystals. In quantitative single-molecule imaging assays in synapses of live neurons, size reduction progressively increases labeling specificity of neurotransmitter receptors. Our findings provide a design roadmap to next-generation QDs with sizes approaching fluorescent protein labels that are the standard of many live-cell biomolecular studies." @default.
- W4229449712 created "2022-05-11" @default.
- W4229449712 creator A5045925125 @default.
- W4229449712 creator A5083126550 @default.
- W4229449712 date "2022-05-09" @default.
- W4229449712 modified "2023-10-17" @default.
- W4229449712 title "Structural Design of Multidentate Copolymers as Compact Quantum Dot Coatings for Live-Cell Single-Particle Imaging" @default.
- W4229449712 cites W1860281480 @default.
- W4229449712 cites W1966656796 @default.
- W4229449712 cites W1970824937 @default.
- W4229449712 cites W1971847993 @default.
- W4229449712 cites W1979260070 @default.
- W4229449712 cites W1979266787 @default.
- W4229449712 cites W1986156969 @default.
- W4229449712 cites W1987924718 @default.
- W4229449712 cites W1994311088 @default.
- W4229449712 cites W1995311028 @default.
- W4229449712 cites W1998265747 @default.
- W4229449712 cites W2006512709 @default.
- W4229449712 cites W2008685387 @default.
- W4229449712 cites W2009331713 @default.
- W4229449712 cites W2009599410 @default.
- W4229449712 cites W2012168285 @default.
- W4229449712 cites W2017870671 @default.
- W4229449712 cites W2018101469 @default.
- W4229449712 cites W2021921508 @default.
- W4229449712 cites W2029667189 @default.
- W4229449712 cites W2034753500 @default.
- W4229449712 cites W2034969680 @default.
- W4229449712 cites W2040540434 @default.
- W4229449712 cites W2041630712 @default.
- W4229449712 cites W2042807740 @default.
- W4229449712 cites W2049354577 @default.
- W4229449712 cites W2054455698 @default.
- W4229449712 cites W2065770997 @default.
- W4229449712 cites W2066521860 @default.
- W4229449712 cites W2073447921 @default.
- W4229449712 cites W2080439652 @default.
- W4229449712 cites W2080550406 @default.
- W4229449712 cites W2081551641 @default.
- W4229449712 cites W2082454728 @default.
- W4229449712 cites W2092547381 @default.
- W4229449712 cites W2094422637 @default.
- W4229449712 cites W2105916176 @default.
- W4229449712 cites W2112067816 @default.
- W4229449712 cites W2126818937 @default.
- W4229449712 cites W2128302316 @default.
- W4229449712 cites W2141083815 @default.
- W4229449712 cites W2146334006 @default.
- W4229449712 cites W2149394130 @default.
- W4229449712 cites W2153971564 @default.
- W4229449712 cites W2230249158 @default.
- W4229449712 cites W2268251385 @default.
- W4229449712 cites W2292437912 @default.
- W4229449712 cites W2305942650 @default.
- W4229449712 cites W2313663240 @default.
- W4229449712 cites W2320628512 @default.
- W4229449712 cites W2327360223 @default.
- W4229449712 cites W2332419660 @default.
- W4229449712 cites W2334034497 @default.
- W4229449712 cites W2335649243 @default.
- W4229449712 cites W2339538625 @default.
- W4229449712 cites W2479032928 @default.
- W4229449712 cites W2560919008 @default.
- W4229449712 cites W2570959551 @default.
- W4229449712 cites W2600278343 @default.
- W4229449712 cites W2799868254 @default.
- W4229449712 cites W2809685476 @default.
- W4229449712 cites W2809917228 @default.
- W4229449712 cites W2895785082 @default.
- W4229449712 cites W2898344414 @default.
- W4229449712 cites W2899274956 @default.
- W4229449712 cites W2916399795 @default.
- W4229449712 cites W2932073682 @default.
- W4229449712 cites W2950712941 @default.
- W4229449712 cites W2966108004 @default.
- W4229449712 cites W2970642949 @default.
- W4229449712 cites W3003060697 @default.
- W4229449712 cites W3008162434 @default.
- W4229449712 cites W3019857627 @default.
- W4229449712 cites W3026930034 @default.
- W4229449712 cites W3035257512 @default.
- W4229449712 cites W3119125141 @default.
- W4229449712 cites W3176290829 @default.
- W4229449712 doi "https://doi.org/10.1021/acs.chemmater.2c00498" @default.
- W4229449712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36968145" @default.
- W4229449712 hasPublicationYear "2022" @default.
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