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- W4229451366 abstract "Abstract Proper embryonic development requires directional axes to pattern cells into embryonic structures. In Drosophila , spatially discrete expression of transcription factors determines the anterior to posterior organization of the early embryo, while the Toll and TGFβ signalling pathways determine the early dorsal to ventral pattern. Embryonic MAPK/ERK signaling contributes to both anterior to posterior patterning in the terminal regions and to dorsal to ventral patterning during oogenesis and embryonic stages. Here we describe a novel loss of function mutation in the Raf kinase gene, which leads to loss of ventral cell fates as seen through the loss of the ventral furrow, the absence of Dorsal/NFκB nuclear localization, the absence of mesoderm determinants Twist and Snail, and the expansion of TGFβ. Gene expression analysis showed cells adopting ectodermal fates much like loss of Toll signaling. Our results combine novel mutants, live imaging, optogenetics and transcriptomics to establish a novel role for Raf, that appears to be independent of the MAPK cascade, in embryonic patterning." @default.
- W4229451366 created "2022-05-11" @default.
- W4229451366 creator A5000188006 @default.
- W4229451366 creator A5019554642 @default.
- W4229451366 creator A5032938186 @default.
- W4229451366 creator A5033983861 @default.
- W4229451366 creator A5035852093 @default.
- W4229451366 creator A5048326991 @default.
- W4229451366 creator A5054629218 @default.
- W4229451366 creator A5058816206 @default.
- W4229451366 date "2022-05-10" @default.
- W4229451366 modified "2023-09-30" @default.
- W4229451366 title "A non-canonical Raf function is required for dorsal–ventral patterning during Drosophila embryogenesis" @default.
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