FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229455318> ?p ?o ?g. }

• W4229455318 endingPage "3448" @default.
• W4229455318 startingPage "3433" @default.
• W4229455318 abstract "We used a real-world database (GuardantINFORMTM) to analyze the treatment choices for patients with mCRC who underwent next-generation sequencing of circulating tumor DNA (ctDNA) using a commercially available test (Guardant360®) after first- or second-line therapy. From 18,875 patients with claims for CRC, 1064 had confirmed metastatic disease and sufficient histories for analysis (median age 59 years, 44.8% female, 44.5% left-sided). ctDNA was detectable for 997/1064 (93.7%) patients. Clinically actionable molecular profiles were present for 507/1064 (47.7%) patients, including those who had not received targeted therapy in the previous line (410/926, 44.3%). Second- or third-line targeted therapies were administered to 338/1064 patients (31.8%) and were considered matched for 193/338 (57.1%) patients. Therapies administered after testing were informed by the ctDNA results in 56.7% of patients overall (603/1064). Time to treatment discontinuation was most favorable for patients with a clinically actionable ctDNA profile who received matched therapy. This analysis demonstrates the real-world clinical value of plasma-based comprehensive genomic profiling for selecting appropriate molecular-targeted therapies in mCRC patients with disease progression after first- or second-line therapy." @default.
• W4229455318 created "2022-05-11" @default.
• W4229455318 creator A5009581933 @default.
• W4229455318 creator A5017122759 @default.
• W4229455318 creator A5026753967 @default.
• W4229455318 creator A5046585715 @default.
• W4229455318 creator A5062748030 @default.
• W4229455318 date "2022-05-09" @default.
• W4229455318 modified "2023-10-18" @default.
• W4229455318 title "Comprehensive Genomic Profiling of Circulating Tumor DNA in Patients with Previously Treated Metastatic Colorectal Cancer: Analysis of a Real-World Healthcare Claims Database" @default.
• W4229455318 cites W1799482054 @default.
• W4229455318 cites W1981513614 @default.
• W4229455318 cites W1997158722 @default.
• W4229455318 cites W2015132197 @default.
• W4229455318 cites W2085633477 @default.
• W4229455318 cites W2095201384 @default.
• W4229455318 cites W2103724490 @default.
• W4229455318 cites W2112570485 @default.
• W4229455318 cites W2131371081 @default.
• W4229455318 cites W2159179344 @default.
• W4229455318 cites W2161375781 @default.
• W4229455318 cites W2164523473 @default.
• W4229455318 cites W2234879572 @default.
• W4229455318 cites W2276287001 @default.
• W4229455318 cites W2601520864 @default.
• W4229455318 cites W2605731475 @default.
• W4229455318 cites W2614443510 @default.
• W4229455318 cites W2751668751 @default.
• W4229455318 cites W2774290425 @default.
• W4229455318 cites W2780582854 @default.
• W4229455318 cites W2783494975 @default.
• W4229455318 cites W2800224623 @default.
• W4229455318 cites W2803558333 @default.
• W4229455318 cites W2891277491 @default.
• W4229455318 cites W2912600727 @default.
• W4229455318 cites W2917710881 @default.
• W4229455318 cites W2921113926 @default.
• W4229455318 cites W2921349646 @default.
• W4229455318 cites W2955389905 @default.
• W4229455318 cites W2963575612 @default.
• W4229455318 cites W2966972050 @default.
• W4229455318 cites W2969669738 @default.
• W4229455318 cites W2977895282 @default.
• W4229455318 cites W2978256016 @default.
• W4229455318 cites W2995701248 @default.
• W4229455318 cites W3009738007 @default.
• W4229455318 cites W3017148673 @default.
• W4229455318 cites W3037016372 @default.
• W4229455318 cites W3040650012 @default.
• W4229455318 cites W3088411120 @default.
• W4229455318 cites W3089353724 @default.
• W4229455318 cites W3108407054 @default.
• W4229455318 cites W3110528877 @default.
• W4229455318 cites W3126601778 @default.
• W4229455318 cites W3138258440 @default.
• W4229455318 cites W3159805754 @default.
• W4229455318 cites W3199014207 @default.
• W4229455318 cites W3212458558 @default.
• W4229455318 cites W4226417570 @default.
• W4229455318 doi "https://doi.org/10.3390/curroncol29050277" @default.
• W4229455318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35621667" @default.
• W4229455318 hasPublicationYear "2022" @default.
• W4229455318 type Work @default.
• W4229455318 citedByCount "1" @default.
• W4229455318 countsByYear W42294553182022 @default.
• W4229455318 crossrefType "journal-article" @default.
• W4229455318 hasAuthorship W4229455318A5009581933 @default.
• W4229455318 hasAuthorship W4229455318A5017122759 @default.
• W4229455318 hasAuthorship W4229455318A5026753967 @default.
• W4229455318 hasAuthorship W4229455318A5046585715 @default.
• W4229455318 hasAuthorship W4229455318A5062748030 @default.
• W4229455318 hasBestOaLocation W42294553181 @default.
• W4229455318 hasConcept C121608353 @default.
• W4229455318 hasConcept C126322002 @default.
• W4229455318 hasConcept C143998085 @default.
• W4229455318 hasConcept C2778715236 @default.
• W4229455318 hasConcept C2779134260 @default.
• W4229455318 hasConcept C2781230642 @default.
• W4229455318 hasConcept C2781335228 @default.
• W4229455318 hasConcept C41008148 @default.
• W4229455318 hasConcept C526805850 @default.
• W4229455318 hasConcept C60644358 @default.
• W4229455318 hasConcept C71924100 @default.
• W4229455318 hasConcept C77088390 @default.
• W4229455318 hasConcept C86803240 @default.
• W4229455318 hasConceptScore W4229455318C121608353 @default.
• W4229455318 hasConceptScore W4229455318C126322002 @default.
• W4229455318 hasConceptScore W4229455318C143998085 @default.
• W4229455318 hasConceptScore W4229455318C2778715236 @default.
• W4229455318 hasConceptScore W4229455318C2779134260 @default.
• W4229455318 hasConceptScore W4229455318C2781230642 @default.
• W4229455318 hasConceptScore W4229455318C2781335228 @default.
• W4229455318 hasConceptScore W4229455318C41008148 @default.
• W4229455318 hasConceptScore W4229455318C526805850 @default.
• W4229455318 hasConceptScore W4229455318C60644358 @default.
• W4229455318 hasConceptScore W4229455318C71924100 @default.
• W4229455318 hasConceptScore W4229455318C77088390 @default.
• W4229455318 hasConceptScore W4229455318C86803240 @default.

• next