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- W4229455468 endingPage "933" @default.
- W4229455468 startingPage "933" @default.
- W4229455468 abstract "As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases. The breakdown of oxidants/antioxidants system happens when the overproduction of free radicals results in an excess over the limitation of cleaning capability, which could lead to the oxidative modification of macromolecules including nucleic acids. The most common type of oxidative base, 8-oxoG, is considered the marker of DNA oxidative damage. The appearance of 8-oxoG could lead to base mismatch and its accumulation might end up as tumorigenesis. The base 8-oxoG was corrected by base excision repair initiated by 8-oxoguanine DNA glycosylase-1 (OGG1), which recognizes 8-oxoG from the genome and excises it from the DNA double strand, generating an AP site for further processing. Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease. This review intends to make an overall summary of the mechanism through which OGG1 regulates gene expression and the role of OGG1 in pulmonary diseases." @default.
- W4229455468 created "2022-05-11" @default.
- W4229455468 creator A5082981111 @default.
- W4229455468 date "2022-05-09" @default.
- W4229455468 modified "2023-09-29" @default.
- W4229455468 title "OGG1 in Lung—More than Base Excision Repair" @default.
- W4229455468 cites W1833739857 @default.
- W4229455468 cites W1964240381 @default.
- W4229455468 cites W1966708146 @default.
- W4229455468 cites W1968477506 @default.
- W4229455468 cites W1972033007 @default.
- W4229455468 cites W1974066333 @default.
- W4229455468 cites W1976987484 @default.
- W4229455468 cites W1978780879 @default.
- W4229455468 cites W1979710783 @default.
- W4229455468 cites W1982714395 @default.
- W4229455468 cites W1985591678 @default.
- W4229455468 cites W1986216062 @default.
- W4229455468 cites W1987768765 @default.
- W4229455468 cites W1988507091 @default.
- W4229455468 cites W1995485603 @default.
- W4229455468 cites W1998100955 @default.
- W4229455468 cites W1998208459 @default.
- W4229455468 cites W2003783360 @default.
- W4229455468 cites W2007391077 @default.
- W4229455468 cites W2009742891 @default.
- W4229455468 cites W2010339813 @default.
- W4229455468 cites W2011507014 @default.
- W4229455468 cites W2014187911 @default.
- W4229455468 cites W2014877928 @default.
- W4229455468 cites W2016004402 @default.
- W4229455468 cites W2030935068 @default.
- W4229455468 cites W2037688224 @default.
- W4229455468 cites W2041084592 @default.
- W4229455468 cites W2041149058 @default.
- W4229455468 cites W2043020194 @default.
- W4229455468 cites W2047576567 @default.
- W4229455468 cites W2049000225 @default.
- W4229455468 cites W2053801105 @default.
- W4229455468 cites W2054200847 @default.
- W4229455468 cites W2054510493 @default.
- W4229455468 cites W2054859516 @default.
- W4229455468 cites W2061919040 @default.
- W4229455468 cites W2064174636 @default.
- W4229455468 cites W2070460687 @default.
- W4229455468 cites W2073061583 @default.
- W4229455468 cites W2073401718 @default.
- W4229455468 cites W2073791969 @default.
- W4229455468 cites W2074353056 @default.
- W4229455468 cites W2077615862 @default.
- W4229455468 cites W2083703501 @default.
- W4229455468 cites W2084505555 @default.
- W4229455468 cites W2087290238 @default.
- W4229455468 cites W2088752888 @default.
- W4229455468 cites W2089263351 @default.
- W4229455468 cites W2089309776 @default.
- W4229455468 cites W2089959863 @default.
- W4229455468 cites W2092790181 @default.
- W4229455468 cites W2093036800 @default.
- W4229455468 cites W2096216481 @default.
- W4229455468 cites W2097706483 @default.
- W4229455468 cites W2097997319 @default.
- W4229455468 cites W2100144658 @default.
- W4229455468 cites W2102096538 @default.
- W4229455468 cites W2103089225 @default.
- W4229455468 cites W2103499809 @default.
- W4229455468 cites W2104454005 @default.
- W4229455468 cites W2105420756 @default.
- W4229455468 cites W2106695363 @default.
- W4229455468 cites W2110440735 @default.
- W4229455468 cites W2111778006 @default.
- W4229455468 cites W2114731011 @default.
- W4229455468 cites W2120118612 @default.
- W4229455468 cites W2121155074 @default.
- W4229455468 cites W2124307421 @default.
- W4229455468 cites W2124821727 @default.
- W4229455468 cites W2129477092 @default.
- W4229455468 cites W2130064337 @default.
- W4229455468 cites W2132766092 @default.
- W4229455468 cites W2133297652 @default.
- W4229455468 cites W2137505881 @default.
- W4229455468 cites W2138976334 @default.
- W4229455468 cites W2145200068 @default.
- W4229455468 cites W2146899007 @default.
- W4229455468 cites W2156460754 @default.
- W4229455468 cites W2163984817 @default.
- W4229455468 cites W2165966433 @default.
- W4229455468 cites W2166691146 @default.
- W4229455468 cites W2169745877 @default.
- W4229455468 cites W2236545012 @default.
- W4229455468 cites W2239639879 @default.
- W4229455468 cites W2331311848 @default.
- W4229455468 cites W2342612813 @default.
- W4229455468 cites W2397885961 @default.
- W4229455468 cites W2466322353 @default.
- W4229455468 cites W248257256 @default.
- W4229455468 cites W2484801831 @default.
- W4229455468 cites W2538723608 @default.