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- W4229455897 abstract "It has been recently reported that, β-Glucans with globular small particle size confer a higher disease resistance due to its induced strong immunomodulating activity. Herein, this work was designed to directly extract the nano β-glucans (NGs) from mushrooms using an acid-base procedure. Two mushrooms, namely, Lentinula edodes (Shiitake) and Pleurotus ostreatus (oyster) mushrooms were used for the production of NGs-s and NGs-o, respectively, through boiling with 0.5 M NaOH for 24 h. The extracted NGs were then characterized using LC-MS, H 1 -NMR, FTIR, SEM, TEM, DLS and UV-Visible spectra. Also, the antitumor activity of NGs was estimated against MCF-7 and HCT-116 cells. Results from LC-MS, proton NMR and FTIR as well as UV–vis analysis affirmed the successful extraction of NGs with the chemical structure of β-glucan when compared with standard β-glucan as a reference. In addition, morphological characteristics of NGs were obtained using SEM and TEM. SEM revealed the porosity of the surface with homogeneous distribution, particularly in the case of NGs-s. TEM also emphasized the formation of NGs of size ranging from 10 to 25 nm and 40–50 nm for NGs-s and NGs-o, respectively, with needle edge shapes as in NGs-s. However, NGs-o showed loosely aggregated irregular shapes which may be attributed to their low zeta potential. In vitro cytotoxicity assays affirmed the potential use of NGs as antitumor materials against carcinoma breast and colon cells at low doses compared to human normal Vero cells. This novel approach opens up opportunities for harnessing mushrooms in the preparation of new cost-effective bioactive products that can be applied in the medical sector. • Extraction of nanoglucan (NGs) from different two kinds of mushrooms. • Acid – base procedure was applied using NaOH (0.5 M). • Formation of NGs with size ranging from 10 to 25 nm and 40–50 nm for NGs-s and NGs-o. • Chemical structure confirmed by FTIR, LC-MS and H 1 NMR analysis." @default.
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- W4229455897 date "2022-08-01" @default.
- W4229455897 modified "2023-09-27" @default.
- W4229455897 title "Facile extraction of nanosized β-glucans from edible mushrooms and their antitumor activities" @default.
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- W4229455897 doi "https://doi.org/10.1016/j.jfca.2022.104607" @default.
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