FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229456463> ?p ?o ?g. }

• W4229456463 endingPage "113085" @default.
• W4229456463 startingPage "113085" @default.
• W4229456463 abstract "The surface of silver nanoparticles (AgNPs) is characterized by high reactivity resulting in prooxidative and cytotoxic properties. These effects are observed both in normal and in cancer cells, which overexpress the Epidermal Growth Factor Receptor (EGFR). In our previous paper, we have demonstrated that, with the use of liposomes labeled with the Epidermal Growth Factor (EGF), it is possible to direct the toxic effect of AgNPs in EGFR-overexpressing cells. Unfortunately, the mechanism of uptake and toxicity induction by such liposomes is still unknown. Therefore, the aim of this study was to determine the impact of EGF-LipoAgNPs on certain genes related to endocytosis and toxicity induction by such liposomes in human lung (A549) and tongue (SCC-15) cancer cells. The siRNA knock-out gene method was used in this study to determine the engagement of EGFR in this process. The confocal microscopy study revealed that the number of liposomes in the cytoplasm of the A549EGFR- and SCC-15EGFR- cells was lowered by 51.99 × 103 RFU and 138.50 × 103 RFU, respectively, proving the crucial role of EGFR in the liposome uptake. Moreover, the expression of the SHH and ATM genes was significantly increased, whereas the expression of the NRF2 gene was decreased after the treatment with EGF-LipoAgNPs and native AgNPs. Furthermore, the expression of the CLTC, AP2M1, CAV1, and SH3GLB1 genes indicated that the tested liposomes are uptaken via the clathrin-dependent pathway with engagement of the AP-2 complex and endophilin in this process. Summarizing, the created targeted delivery system of AgNPs causes an increase in the prooxidative and toxic effect of such NPs and has an impact on endocytosis regulatory genes, especially those related to the clathrin-mediated endocytosis." @default.
• W4229456463 created "2022-05-11" @default.
• W4229456463 creator A5046861563 @default.
• W4229456463 creator A5049449423 @default.
• W4229456463 date "2022-06-01" @default.
• W4229456463 modified "2023-09-26" @default.
• W4229456463 title "Molecular mechanism of the uptake and toxicity of EGF-LipoAgNPs in EGFR-overexpressing cancer cells" @default.
• W4229456463 cites W1929867252 @default.
• W4229456463 cites W1989610711 @default.
• W4229456463 cites W1993355802 @default.
• W4229456463 cites W1994604625 @default.
• W4229456463 cites W1999046321 @default.
• W4229456463 cites W2003110090 @default.
• W4229456463 cites W2018634829 @default.
• W4229456463 cites W2081678833 @default.
• W4229456463 cites W2083973451 @default.
• W4229456463 cites W2087024653 @default.
• W4229456463 cites W2117824758 @default.
• W4229456463 cites W2129739125 @default.
• W4229456463 cites W2194128360 @default.
• W4229456463 cites W2298851722 @default.
• W4229456463 cites W2321369253 @default.
• W4229456463 cites W2574979331 @default.
• W4229456463 cites W2588452551 @default.
• W4229456463 cites W2610431205 @default.
• W4229456463 cites W2746575666 @default.
• W4229456463 cites W2750282822 @default.
• W4229456463 cites W2754383668 @default.
• W4229456463 cites W2768246206 @default.
• W4229456463 cites W2770975967 @default.
• W4229456463 cites W2790453103 @default.
• W4229456463 cites W2794692906 @default.
• W4229456463 cites W2796054394 @default.
• W4229456463 cites W2801079612 @default.
• W4229456463 cites W2914285571 @default.
• W4229456463 cites W2922440898 @default.
• W4229456463 cites W2949036789 @default.
• W4229456463 cites W3006508170 @default.
• W4229456463 cites W3010076284 @default.
• W4229456463 cites W3037707998 @default.
• W4229456463 cites W3042552067 @default.
• W4229456463 cites W3097290503 @default.
• W4229456463 cites W3111725549 @default.
• W4229456463 cites W3135875197 @default.
• W4229456463 cites W3175441751 @default.
• W4229456463 cites W3190257656 @default.
• W4229456463 cites W4223529416 @default.
• W4229456463 doi "https://doi.org/10.1016/j.biopha.2022.113085" @default.
• W4229456463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35658239" @default.
• W4229456463 hasPublicationYear "2022" @default.
• W4229456463 type Work @default.
• W4229456463 citedByCount "3" @default.
• W4229456463 countsByYear W42294564632023 @default.
• W4229456463 crossrefType "journal-article" @default.
• W4229456463 hasAuthorship W4229456463A5046861563 @default.
• W4229456463 hasAuthorship W4229456463A5049449423 @default.
• W4229456463 hasBestOaLocation W42294564631 @default.
• W4229456463 hasConcept C109316439 @default.
• W4229456463 hasConcept C121608353 @default.
• W4229456463 hasConcept C153911025 @default.
• W4229456463 hasConcept C170493617 @default.
• W4229456463 hasConcept C178790620 @default.
• W4229456463 hasConcept C185154212 @default.
• W4229456463 hasConcept C185592680 @default.
• W4229456463 hasConcept C202751555 @default.
• W4229456463 hasConcept C2776362946 @default.
• W4229456463 hasConcept C2779438470 @default.
• W4229456463 hasConcept C28005876 @default.
• W4229456463 hasConcept C29730261 @default.
• W4229456463 hasConcept C502942594 @default.
• W4229456463 hasConcept C54355233 @default.
• W4229456463 hasConcept C55493867 @default.
• W4229456463 hasConcept C86803240 @default.
• W4229456463 hasConcept C95444343 @default.
• W4229456463 hasConcept C96232424 @default.
• W4229456463 hasConceptScore W4229456463C109316439 @default.
• W4229456463 hasConceptScore W4229456463C121608353 @default.
• W4229456463 hasConceptScore W4229456463C153911025 @default.
• W4229456463 hasConceptScore W4229456463C170493617 @default.
• W4229456463 hasConceptScore W4229456463C178790620 @default.
• W4229456463 hasConceptScore W4229456463C185154212 @default.
• W4229456463 hasConceptScore W4229456463C185592680 @default.
• W4229456463 hasConceptScore W4229456463C202751555 @default.
• W4229456463 hasConceptScore W4229456463C2776362946 @default.
• W4229456463 hasConceptScore W4229456463C2779438470 @default.
• W4229456463 hasConceptScore W4229456463C28005876 @default.
• W4229456463 hasConceptScore W4229456463C29730261 @default.
• W4229456463 hasConceptScore W4229456463C502942594 @default.
• W4229456463 hasConceptScore W4229456463C54355233 @default.
• W4229456463 hasConceptScore W4229456463C55493867 @default.
• W4229456463 hasConceptScore W4229456463C86803240 @default.
• W4229456463 hasConceptScore W4229456463C95444343 @default.
• W4229456463 hasConceptScore W4229456463C96232424 @default.
• W4229456463 hasFunder F4320328484 @default.
• W4229456463 hasLocation W42294564631 @default.
• W4229456463 hasLocation W42294564632 @default.
• W4229456463 hasOpenAccess W4229456463 @default.
• W4229456463 hasPrimaryLocation W42294564631 @default.

• next