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• W4229457562 startingPage "5269" @default.
• W4229457562 abstract "The Warburg effect is commonly recognized as a hallmark of nearly all tumors. In prostate cancer (PCa), it has been shown to be driven by PTEN loss- and Akt hyperactivation-associated upregulation of hexokinase 2 (HK2). δ-Tocotrienol (δ-TT) is an extensively studied antitumor compound; however, its role in affecting PCa glycolysis is still unclear. Herein, we demonstrated that δ-TT inhibits glucose uptake and lactate production in PTEN-deficient LNCaP and PC3 PCa cells, by specifically decreasing HK2 expression. Notably, this was accompanied by the inhibition of the Akt pathway. Moreover, the nutraceutical could synergize with the well-known hypoglycemic agent metformin in inducing PCa cell death, highlighting the crucial role of the above metabolic phenotype in δ-TT-mediated cytotoxicity. Collectively, these results unravel novel inhibitory effects of δ-TT on glycolytic reprogramming in PCa, thus providing new perspectives into the mechanisms of its antitumor activity and into its use in combination therapy." @default.
• W4229457562 created "2022-05-11" @default.
• W4229457562 creator A5070288427 @default.
• W4229457562 creator A5081336487 @default.
• W4229457562 date "2022-05-09" @default.
• W4229457562 modified "2023-10-05" @default.
• W4229457562 title "Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for δ-Tocotrienol" @default.
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• W4229457562 doi "https://doi.org/10.3390/ijms23095269" @default.
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• W4229457562 hasPublicationYear "2022" @default.
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