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- W4229459739 abstract "Abstract Objective: To investigate the clinical characteristics, pathological features, and outcomes of patients with antineutrophil cytoplasmic antibodies (ANCA)-positive systemic lupus erythematosus (SLE) in northwest China. Methods: We conducted a retrospective study of an ANCA-positive SLE cohort from 2012 to 2019. Clinical characteristics, laboratory data, renal histological features, and outcomes were analyzed. Patients diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) with renal involvement, excluding those with SLE and ANCA-negative lupus nephritis (LN), were randomly selected as controls. Results: A total of 49 ANCA-positive LN patients were included in this study. The enrolled patients had a significantly lower estimated glomerular filtration rate (eGFR) than ANCA-negative LN patients and had a higher eGFR than AAV patients. SLE patients with MPO-ANCA had higher levels of serum creatinine (CREA) and blood urea nitrogen (BUN) than those with PR3-ANCA (CREA:156.5 µmol/L vs. 45.5 µmol/L, P = 0.005; BUN: 12.77 µmol/L vs 4.27 µmol/L, P = 0.005, respectively). ANCA titers positively correlated with serum complement levels in patients with SLE. ANCA-positive LN cases had a significantly higher percentage of tubulointerstitial fibrosis (84.6% vs. 14.3%, P < 0.001) and higher median glomerular chronicity index (2.1 vs. 0.9, P = 0.017) than ANCA-negative LN patients. During follow-up, there were significant differences in the proteinuria remission rates between the two matched groups when using propensity scoring ( P = 0.008). Conclusion: ANCA-positive SLE patients may have worse baseline renal function (especially those with MPO-ANCA positivity) and lower protein remission rates. During the follow-up period, a decrease in ANCA titer seems to correlate with renal function improvement. ANCA titers should be regularly monitored throughout the follow-up period of SLE patients, especially when there is renal involvement." @default.
- W4229459739 created "2022-05-11" @default.
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- W4229459739 date "2022-05-09" @default.
- W4229459739 modified "2023-10-16" @default.
- W4229459739 title "Clinical features and outcomes of patients with antineutrophil cytoplasmic antibody-positive systemic lupus erythematosus" @default.
- W4229459739 doi "https://doi.org/10.21203/rs.3.rs-1624967/v1" @default.
- W4229459739 hasPublicationYear "2022" @default.
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