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- W4229485619 abstract "The prognostic implications of t(9;22)(q34;q11) were assessed at a median follow-up of 3.5 years in 434 children receiving intensive treatment for acute lymphoblastic leukemia (ALL). Four-year event-free and overall survivals were 81% and 88%, respectively, in 419 children lacking t(9;22), but were 0% and 20%, respectively, in 15 children with t(9;22) (P less than .001). Poor outcome for children with t(9;22)- positive ALL was particularly notable because we have reported improved survival in other historically poor prognosis ALL cytogenetic categories when treated with similarly intensive therapy. We recommend that very intensive treatment approaches, including bone marrow transplantation in first remission, be considered for all children with t(9;22)-positive ALL." @default.
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- W4229485619 date "1991-02-01" @default.
- W4229485619 modified "2023-09-27" @default.
- W4229485619 title "Translocation (9;22) is associated with extremely poor prognosis in intensively treated children with acute lymphoblastic leukemia" @default.
- W4229485619 doi "https://doi.org/10.1182/blood.v77.3.435.bloodjournal773435" @default.
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