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- W4229508230 endingPage "242" @default.
- W4229508230 startingPage "233" @default.
- W4229508230 abstract "The molecular chaperones are a diverse set of protein families required for the correct folding, transport and degradation of other proteins in vivo. There has been great progress in understanding the structure and mechanism of action of the chaperonin family, exemplified by Escherichia coli GroEL. The chaperonins are large, double-ring oligomeric proteins that act as containers for the folding of other protein subunits. Together with its co-protein GroES, GroEL binds non-native polypeptides and facilitates their refolding in an ATP-dependent manner. The action of the ATPase cycle causes the substrate-binding surface of GroEL to alternate in character between hydrophobic (binding/unfolding) and hydrophilic (release/folding). ATP binding initiates a series of dramatic conformational changes that bury the substrate-binding sites, lowering the affinity for non-native polypeptide. In the presence of ATP, GroES binds to GroEL, forming a large chamber that encapsulates substrate proteins for folding. For proteins whose folding is absolutely dependent on the full GroE system, ATP binding (but not hydrolysis) in the encapsulating ring is needed to initiate protein folding. Similarly, ATP binding, but not hydrolysis, in the opposite GroEL ring is needed to release GroES, thus opening the chamber. If the released substrate protein is still not correctly folded, it will go through another round of interaction with GroEL." @default.
- W4229508230 created "2022-05-11" @default.
- W4229508230 creator A5021508521 @default.
- W4229508230 creator A5022477994 @default.
- W4229508230 creator A5025814244 @default.
- W4229508230 date "1998-07-15" @default.
- W4229508230 modified "2023-10-17" @default.
- W4229508230 title "Chaperonins" @default.
- W4229508230 cites W1482559205 @default.
- W4229508230 cites W1488480847 @default.
- W4229508230 cites W1498543655 @default.
- W4229508230 cites W1519072595 @default.
- W4229508230 cites W1524477594 @default.
- W4229508230 cites W1531453124 @default.
- W4229508230 cites W1541948779 @default.
- W4229508230 cites W1543646430 @default.
- W4229508230 cites W1583668498 @default.
- W4229508230 cites W1583838105 @default.
- W4229508230 cites W1608877318 @default.
- W4229508230 cites W1646791064 @default.
- W4229508230 cites W1809320936 @default.
- W4229508230 cites W1892996896 @default.
- W4229508230 cites W1965255559 @default.
- W4229508230 cites W1966760093 @default.
- W4229508230 cites W1970007744 @default.
- W4229508230 cites W1970388314 @default.
- W4229508230 cites W1971090714 @default.
- W4229508230 cites W1974347829 @default.
- W4229508230 cites W1975460230 @default.
- W4229508230 cites W1980467950 @default.
- W4229508230 cites W1980627844 @default.
- W4229508230 cites W1982580121 @default.
- W4229508230 cites W1984831405 @default.
- W4229508230 cites W1989999739 @default.
- W4229508230 cites W1990634143 @default.
- W4229508230 cites W1996645786 @default.
- W4229508230 cites W1996974151 @default.
- W4229508230 cites W1998960610 @default.
- W4229508230 cites W1999119754 @default.
- W4229508230 cites W2000204824 @default.
- W4229508230 cites W2000363955 @default.
- W4229508230 cites W2002542088 @default.
- W4229508230 cites W2003080309 @default.
- W4229508230 cites W2014880911 @default.
- W4229508230 cites W2017886114 @default.
- W4229508230 cites W2022796050 @default.
- W4229508230 cites W2027680201 @default.
- W4229508230 cites W2027739701 @default.
- W4229508230 cites W2028682933 @default.
- W4229508230 cites W2029265132 @default.
- W4229508230 cites W2034943952 @default.
- W4229508230 cites W2036289025 @default.
- W4229508230 cites W2039230345 @default.
- W4229508230 cites W2040164455 @default.
- W4229508230 cites W2040721595 @default.
- W4229508230 cites W2041052616 @default.
- W4229508230 cites W2044106262 @default.
- W4229508230 cites W2045339530 @default.
- W4229508230 cites W2045777307 @default.
- W4229508230 cites W2046872769 @default.
- W4229508230 cites W2047983557 @default.
- W4229508230 cites W2048906768 @default.
- W4229508230 cites W2051664333 @default.
- W4229508230 cites W2051793369 @default.
- W4229508230 cites W2052357124 @default.
- W4229508230 cites W2053855935 @default.
- W4229508230 cites W2055416608 @default.
- W4229508230 cites W2058888270 @default.
- W4229508230 cites W2060644195 @default.
- W4229508230 cites W2070989276 @default.
- W4229508230 cites W2076945013 @default.
- W4229508230 cites W2078248419 @default.
- W4229508230 cites W2080906358 @default.
- W4229508230 cites W2080980515 @default.
- W4229508230 cites W2081422975 @default.
- W4229508230 cites W2081443283 @default.
- W4229508230 cites W2082250659 @default.
- W4229508230 cites W2085628457 @default.
- W4229508230 cites W2098665638 @default.
- W4229508230 cites W2100986312 @default.
- W4229508230 cites W2105799023 @default.
- W4229508230 cites W2106315897 @default.
- W4229508230 cites W2112133866 @default.
- W4229508230 cites W2119999468 @default.
- W4229508230 cites W2127033103 @default.
- W4229508230 cites W2129214482 @default.
- W4229508230 cites W2138749342 @default.
- W4229508230 cites W2139306838 @default.
- W4229508230 cites W2142338805 @default.
- W4229508230 cites W2142955330 @default.
- W4229508230 cites W2147739915 @default.
- W4229508230 cites W2164028851 @default.
- W4229508230 cites W2166345972 @default.
- W4229508230 cites W2310956174 @default.
- W4229508230 cites W315652573 @default.
- W4229508230 doi "https://doi.org/10.1042/bj3330233" @default.
- W4229508230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9657960" @default.
- W4229508230 hasPublicationYear "1998" @default.