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- W4229511123 abstract "This chapter reviews those primary cutaneous lymphoproliferative lesions that derive from CD8-positive lymphocytes, including neoplastic disorders of CD8-positive lymphocytes, which are primary to the skin, and those in which secondary skin involvement is not uncommon. In primary cutaneous aggressive epidermotropic CD8+ cytotoxic T cell lymphoma, there may be acanthosis and pseudoepitheliomatous hyperplasia of the epidermis, with epidermotropism in excess of that encountered in typical mycosis fungoides cases, often associated with prominent keratinocyte necrosis and sometimes with subepidermal bulla formation. Lymphomatoid papulosis has a cytomorphology, phenotype, and molecular profile suggesting a malignant neoplastic process, but a clinical course that is typical of benign disease, being one of spontaneous regression. Patients with human immunodeficiency virus (HIV) infection can develop a characteristic skin eruption typified by massive infiltration of the epidermis and dermis by CD8 lymphocytes, presumably representing a response to HIV-associated viral anti." @default.
- W4229511123 created "2022-05-11" @default.
- W4229511123 date "2016-01-01" @default.
- W4229511123 modified "2023-09-23" @default.
- W4229511123 title "CD8 T Cell Lymphoproliferative Disease of the Skin" @default.
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- W4229511123 doi "https://doi.org/10.1002/9781118776193.ch16" @default.
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