Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229532484> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4229532484 abstract "Vascular dysfunction, characterized by arterial stiffness and endothelial dysfunction, represents an important link between obesity and cardiovascular disease. Deleterious changes to the gut microbiome, termed dysbiosis, are associated with obesity and may contribute to the development of vascular dysfunction by promoting systemic and arterial inflammation. We tested the hypothesis that antibiotic treatment in diet-induced obese mice would improve vascular function by suppressing potentially harmful gut-derived bacterial products to reduce dysbiosis-related inflammation. Male C57BL/6 mice were fed either a standard diet (SD) or Western diet (WD) for 5 months. Obese WD-fed mice were then randomized to receive 8 weeks of antibiotic treatment via drinking water. Arterial stiffness was measured via in vivo aortic pulse wave velocity and endothelial function assessed via ex vivo pressure myography in isolated mesenteric arteries. Plasma and arterial tissue samples were collected for measures of endotoxemia and inflammation and fecal samples were collected for microbial sequencing. Our results showed that mice fed a WD for 5 months had significantly higher body weight and arterial stiffness compared to SD. Antibiotic treatment significantly reduced arterial stiffness in WD-fed mice without affecting body weight. Endothelial function was impaired in WD-fed mice, whereas WD-Abx mice had similar endothelial function to SD-fed mice. Plasma levels of the pro-inflammatory cytokine IL-6 and endotoxemia marker LPS binding protein (LBP) were significantly increased in WD vs SD, but reduced in WD-Abx vs WD. Gut microbial suppression with antibiotic treatment was confirmed using quantitative PCR and ongoing analyses are being conducted to determine specific diet-induced changes to the composition of the gut microbiome. Overall, our results support the hypothesis that gut dysbiosis contributes the development of vascular dysfunction in obesity and provide evidence that a gut-targeted therapy can improve endothelial function and arterial stiffness in diet-induced obese mice. Future studies will further examine the mechanisms involved in, and help identify potential therapeutic targets for, obesity-related vascular dysfunction." @default.
- W4229532484 created "2022-05-11" @default.
- W4229532484 creator A5033657834 @default.
- W4229532484 creator A5034128223 @default.
- W4229532484 creator A5038162906 @default.
- W4229532484 creator A5038973346 @default.
- W4229532484 creator A5069776188 @default.
- W4229532484 creator A5074434157 @default.
- W4229532484 creator A5075926426 @default.
- W4229532484 date "2017-07-21" @default.
- W4229532484 modified "2023-09-27" @default.
- W4229532484 title "Abstract 165: Role of the Gut Microbiome in Obesity-Related Vascular Dysfunction" @default.
- W4229532484 doi "https://doi.org/10.1161/res.121.suppl_1.165" @default.
- W4229532484 hasPublicationYear "2017" @default.
- W4229532484 type Work @default.
- W4229532484 citedByCount "0" @default.
- W4229532484 crossrefType "journal-article" @default.
- W4229532484 hasAuthorship W4229532484A5033657834 @default.
- W4229532484 hasAuthorship W4229532484A5034128223 @default.
- W4229532484 hasAuthorship W4229532484A5038162906 @default.
- W4229532484 hasAuthorship W4229532484A5038973346 @default.
- W4229532484 hasAuthorship W4229532484A5069776188 @default.
- W4229532484 hasAuthorship W4229532484A5074434157 @default.
- W4229532484 hasAuthorship W4229532484A5075926426 @default.
- W4229532484 hasConcept C120770815 @default.
- W4229532484 hasConcept C126322002 @default.
- W4229532484 hasConcept C134018914 @default.
- W4229532484 hasConcept C143121216 @default.
- W4229532484 hasConcept C150903083 @default.
- W4229532484 hasConcept C1918360 @default.
- W4229532484 hasConcept C203014093 @default.
- W4229532484 hasConcept C207001950 @default.
- W4229532484 hasConcept C26291073 @default.
- W4229532484 hasConcept C2775850156 @default.
- W4229532484 hasConcept C2776252253 @default.
- W4229532484 hasConcept C2776820930 @default.
- W4229532484 hasConcept C2776914184 @default.
- W4229532484 hasConcept C2777165150 @default.
- W4229532484 hasConcept C2778319312 @default.
- W4229532484 hasConcept C2780771799 @default.
- W4229532484 hasConcept C2780972559 @default.
- W4229532484 hasConcept C539455810 @default.
- W4229532484 hasConcept C60644358 @default.
- W4229532484 hasConcept C71924100 @default.
- W4229532484 hasConcept C84393581 @default.
- W4229532484 hasConcept C86803240 @default.
- W4229532484 hasConceptScore W4229532484C120770815 @default.
- W4229532484 hasConceptScore W4229532484C126322002 @default.
- W4229532484 hasConceptScore W4229532484C134018914 @default.
- W4229532484 hasConceptScore W4229532484C143121216 @default.
- W4229532484 hasConceptScore W4229532484C150903083 @default.
- W4229532484 hasConceptScore W4229532484C1918360 @default.
- W4229532484 hasConceptScore W4229532484C203014093 @default.
- W4229532484 hasConceptScore W4229532484C207001950 @default.
- W4229532484 hasConceptScore W4229532484C26291073 @default.
- W4229532484 hasConceptScore W4229532484C2775850156 @default.
- W4229532484 hasConceptScore W4229532484C2776252253 @default.
- W4229532484 hasConceptScore W4229532484C2776820930 @default.
- W4229532484 hasConceptScore W4229532484C2776914184 @default.
- W4229532484 hasConceptScore W4229532484C2777165150 @default.
- W4229532484 hasConceptScore W4229532484C2778319312 @default.
- W4229532484 hasConceptScore W4229532484C2780771799 @default.
- W4229532484 hasConceptScore W4229532484C2780972559 @default.
- W4229532484 hasConceptScore W4229532484C539455810 @default.
- W4229532484 hasConceptScore W4229532484C60644358 @default.
- W4229532484 hasConceptScore W4229532484C71924100 @default.
- W4229532484 hasConceptScore W4229532484C84393581 @default.
- W4229532484 hasConceptScore W4229532484C86803240 @default.
- W4229532484 hasIssue "suppl_1" @default.
- W4229532484 hasLocation W42295324841 @default.
- W4229532484 hasOpenAccess W4229532484 @default.
- W4229532484 hasPrimaryLocation W42295324841 @default.
- W4229532484 hasRelatedWork W1586081684 @default.
- W4229532484 hasRelatedWork W2460485512 @default.
- W4229532484 hasRelatedWork W2754781643 @default.
- W4229532484 hasRelatedWork W2791660044 @default.
- W4229532484 hasRelatedWork W2904878795 @default.
- W4229532484 hasRelatedWork W3040954058 @default.
- W4229532484 hasRelatedWork W3176409244 @default.
- W4229532484 hasRelatedWork W3215350371 @default.
- W4229532484 hasRelatedWork W4225374916 @default.
- W4229532484 hasRelatedWork W4229532484 @default.
- W4229532484 hasVolume "121" @default.
- W4229532484 isParatext "false" @default.
- W4229532484 isRetracted "false" @default.
- W4229532484 workType "article" @default.