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- W4229553302 abstract "Molecular analysis of polypeptides and antigens of Treponema pallidum has been used increasingly during the past 5 years in investigation of the immunology, pathogenicity and molecular biology of this organism. Failure to culture the organism has severely limited our knowledge of its constituent polypeptides and antigens, but many profiles of these unknown constituents, revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting techniques have been published. In order to compare meaningfully the results obtained by different groups, we have identified a standard pattern of prominent ‘landmark’ polypeptides in such gel profiles and where possible have assigned functional identities to them. A preliminary nomenclature for the prominent polypeptides of T. pallidum is proposed. These are: P1, 80 kDa; P2, 60 kDa; P3, 47 kDa, an outer membrane-associated polypeptide; P4, 40 kDa; P5, 37 kDa, the major polypeptide of the axial filament; P6, 34 kDa; and P7, 31.5 kDa." @default.
- W4229553302 created "2022-05-11" @default.
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- W4229553302 date "1986-04-01" @default.
- W4229553302 modified "2023-09-25" @default.
- W4229553302 title "Molecular and immunochemical analysis of Treponema pallidum" @default.
- W4229553302 doi "https://doi.org/10.1016/0378-1097(86)90285-5" @default.
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