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- W4229553635 abstract "Physicians and biomedical scientists, from many countries, gathered in Prague in October 1996 to discuss current knowledge of the mechanisms responsible for one of our most common disease processes atherosclerosis and current options for its treatment. Recent research has shed light on several mechanisms, including lipoprotein oxidation and endothelial shear stresses, which are only now being recognised as central components of the disease. Evidence of the pivotal role which appears to be assumed by oxidized lipids, together with other insights into the disease, such as the involvement of immunological responses, were presented during the first session of the meeting to give an overview of atherosclerotic mechanisms. The second session concentrated on the clinical manifestations of peripheral occlusive arterial disease (POAD), specifically intermittent claudication, and the often dramatic improvement in the quality of life which may be experienced by patients as a result of the use of effective treatments. Where appropriate, parallels were drawn between therapeutic approaches and the mechanistic evidence described in Session 1 to emphasise the cellular and molecular modifications by which symptomatic improvements may be achieved. This highlighted the types of therapy which are likely to prove most effective, both in clinical practice and economically, together with the approaches which offer most promise for future intervention.The meeting was sponsored by Hoechst Marion Roussel.Guest EditorsGeert Schmid-Schönbein and Seymour Glagov" @default.
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- W4229553635 date "1997-06-01" @default.
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- W4229553635 title "Introduction" @default.
- W4229553635 doi "https://doi.org/10.1016/s0021-9150(97)06113-3" @default.
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