Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229691925> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4229691925 abstract "Abstract Background: Myofascial pain syndrome (MPS) is a prevalent chronic pain disorder primarily characterized by myofascial trigger points (MTrP). There is limited knowledge on the pathophysiology and mechanisms underlying MTrP and its development. Research has previously demonstrated the identification of MTrPs using ultrasound and vibration sonoelastography, although there is some contradictory evidence regarding if MTrPs present as hyper or hypoechoic regions. Electromyography (EMG) investigations of MTrP have demonstrated that MTrP are usually located proximal to innervation zones where the peak surface EMG signals are obtained from. Central sensitization has been proposed as the primary mechanism underlying MTrP development. Central sensitization is associated with hyperexcitability of neuronal responses to normal or noxious stimuli. There is a need for a study that measures ultrasound image textural changes and motor unit activity responses in the muscle following sensitization. The purpose of this study is to determine whether sensitizing healthy muscle using capsaicin induces a regional change in image texture variables within the specific and surrounding muscles, as well as the motor unit frequency and amplitude changes that accompany them.This is an exploratory trial that aims to provide preliminary evidence on whether central sensitization is a direct cause of taut band and MTrP development. Methods: The study conforms to the Consolidated Standards of Reporting Trials recommendations. Ethical approval will be sought from the University Health Network (UHN) Research Ethics Board. This proposed study is a single centered, factorial, randomized placebo-controlled trial with two independent variables, depth of capsaicin application and dose of capsaicin, for a total of four treatment arms and two control treatment groups. Discussion: This will be the first study that assesses the B-mode ultrasound image texture of induced sensitized muscles, and will provide more evidence on muscle motor unit activity and regional changes of central sensitization. Findings from this study may support one of few hypotheses proposed delineating the involvement of central sensitization in the development of trigger points." @default.
- W4229691925 created "2022-05-11" @default.
- W4229691925 creator A5030430929 @default.
- W4229691925 creator A5057360997 @default.
- W4229691925 creator A5058129501 @default.
- W4229691925 creator A5088892368 @default.
- W4229691925 date "2019-07-25" @default.
- W4229691925 modified "2023-10-16" @default.
- W4229691925 title "Quantitative Response of Healthy Muscle Following the Induction of Capsaicin: An Exploratory Randomized Controlled Trial" @default.
- W4229691925 doi "https://doi.org/10.21203/rs.2.11950/v1" @default.
- W4229691925 hasPublicationYear "2019" @default.
- W4229691925 type Work @default.
- W4229691925 citedByCount "0" @default.
- W4229691925 crossrefType "posted-content" @default.
- W4229691925 hasAuthorship W4229691925A5030430929 @default.
- W4229691925 hasAuthorship W4229691925A5057360997 @default.
- W4229691925 hasAuthorship W4229691925A5058129501 @default.
- W4229691925 hasAuthorship W4229691925A5088892368 @default.
- W4229691925 hasBestOaLocation W42296919251 @default.
- W4229691925 hasConcept C126322002 @default.
- W4229691925 hasConcept C14184104 @default.
- W4229691925 hasConcept C142724271 @default.
- W4229691925 hasConcept C15490471 @default.
- W4229691925 hasConcept C15744967 @default.
- W4229691925 hasConcept C168563851 @default.
- W4229691925 hasConcept C169760540 @default.
- W4229691925 hasConcept C170493617 @default.
- W4229691925 hasConcept C1862650 @default.
- W4229691925 hasConcept C204787440 @default.
- W4229691925 hasConcept C27081682 @default.
- W4229691925 hasConcept C2776217527 @default.
- W4229691925 hasConcept C2779316685 @default.
- W4229691925 hasConcept C2780051329 @default.
- W4229691925 hasConcept C2781118164 @default.
- W4229691925 hasConcept C3019020247 @default.
- W4229691925 hasConcept C535046627 @default.
- W4229691925 hasConcept C71924100 @default.
- W4229691925 hasConcept C99508421 @default.
- W4229691925 hasConceptScore W4229691925C126322002 @default.
- W4229691925 hasConceptScore W4229691925C14184104 @default.
- W4229691925 hasConceptScore W4229691925C142724271 @default.
- W4229691925 hasConceptScore W4229691925C15490471 @default.
- W4229691925 hasConceptScore W4229691925C15744967 @default.
- W4229691925 hasConceptScore W4229691925C168563851 @default.
- W4229691925 hasConceptScore W4229691925C169760540 @default.
- W4229691925 hasConceptScore W4229691925C170493617 @default.
- W4229691925 hasConceptScore W4229691925C1862650 @default.
- W4229691925 hasConceptScore W4229691925C204787440 @default.
- W4229691925 hasConceptScore W4229691925C27081682 @default.
- W4229691925 hasConceptScore W4229691925C2776217527 @default.
- W4229691925 hasConceptScore W4229691925C2779316685 @default.
- W4229691925 hasConceptScore W4229691925C2780051329 @default.
- W4229691925 hasConceptScore W4229691925C2781118164 @default.
- W4229691925 hasConceptScore W4229691925C3019020247 @default.
- W4229691925 hasConceptScore W4229691925C535046627 @default.
- W4229691925 hasConceptScore W4229691925C71924100 @default.
- W4229691925 hasConceptScore W4229691925C99508421 @default.
- W4229691925 hasLocation W42296919251 @default.
- W4229691925 hasLocation W42296919252 @default.
- W4229691925 hasLocation W42296919253 @default.
- W4229691925 hasLocation W42296919254 @default.
- W4229691925 hasOpenAccess W4229691925 @default.
- W4229691925 hasPrimaryLocation W42296919251 @default.
- W4229691925 hasRelatedWork W198100430 @default.
- W4229691925 hasRelatedWork W2089933404 @default.
- W4229691925 hasRelatedWork W2096019576 @default.
- W4229691925 hasRelatedWork W2105237780 @default.
- W4229691925 hasRelatedWork W2156762213 @default.
- W4229691925 hasRelatedWork W2745987926 @default.
- W4229691925 hasRelatedWork W2885857303 @default.
- W4229691925 hasRelatedWork W29195018 @default.
- W4229691925 hasRelatedWork W4232396799 @default.
- W4229691925 hasRelatedWork W44438419 @default.
- W4229691925 isParatext "false" @default.
- W4229691925 isRetracted "false" @default.
- W4229691925 workType "article" @default.