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• W4229692692 abstract "The rebuttal of Ngoepe and Ventikos makes it clear that the authors need the simulated TG curves to be a realistic representation of the relation between clotting factor concentrations in plasma and the resulting thrombin generation curve, but used the Wagenvoord model 1.Wagenvoord R. Hemker P.W. Hemker H.C. The limits of simulation of the clotting system.J Thromb Haemost. 2006; 4: 1331-8Crossref PubMed Scopus (45) Google Scholar as a mathematical method to obtain a time course of thrombin generation resembling a real‐life thrombin generation curve. This is a perfectly legitimate way to use the mock model. We regret that we misunderstood this but are glad to have provoked the clarification of a point that also might have escaped more readers. We might even have suggested that even deliberately imperfect simulation models can make physiological sense. If, however, Ngoepe and Ventikos want to generate a time course of thrombin that perfectly resembles real thrombin generation curves, it is more practical to use the analytical formula that we derived for that purpose, that is 1.Wagenvoord R. Hemker P.W. Hemker H.C. The limits of simulation of the clotting system.J Thromb Haemost. 2006; 4: 1331-8Crossref PubMed Scopus (45) Google Scholar, 2.Hemker H.C. Kremers R. Data management in thrombin generation.Thromb Res. 2013; 131: 3-11Abstract Full Text Full Text PDF PubMed Scopus (86) Google Scholar:THROMBIN=e·PEAK·exp[−e·(t−TTP)]·PEAK/ETP·exp[−exp[−e·(t−TTP)·PEAK/ETP]]where e = 2.7272, ETP = area under the thrombin generation curve in nm min, PEAK = peak height of the thrombin generation curve in nM, and TTP = time to peak in min. This formula simplifies calculation because no numerical solution of stiff differential equations is required and it reduces the number of variables from 14 to 3. Moreover, the required variables can be directly found from real‐life measurements of thrombin generation (e.g. from the average of a set of normal plasmas or from values that are found in an individual patient). The authors state that they have no conflict of interest." @default.
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• W4229692692 date "2017-02-01" @default.
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• W4229692692 title "Computational modelling of clot development in patient‐specific cerebral aneurysm cases: rebuttal" @default.
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• W4229692692 doi "https://doi.org/10.1111/jth.13593" @default.
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