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- W4229692694 abstract "We studied by fluorescence in situ hybridization the frequency of aneuploidy in spermatozoa of 12 infertile men: 8 with normal or nearly normal semen analysis values and 4 with oligo-astheno-teratozoospermia. The control group consisted of 18 normal healthy fertile men. Probes for chromosome 1 and 7 were used and 10,000 spermatozoa per individual were scored. The hybridization efficiency was good (higher than 98%). In the group with nearly normal semen analysis values the frequencies of spermatozoa disomic for chromosome 1 or chromosome 7 were 0.08% and 0.07%, respectively, and not elevated compared to controls (0.10% and 0.06%, respectively). The frequency of diploid spermatozoa was 0.17%, not significantly different from the control group (0.15%) either. In the group of oligo-astheno-teratozoospermic men both the frequencies of disomic cells for chromosome 1 (0.22%) and for chromosome 7 (0.13%) and of diploid spermatozoa (0.56%) were significantly higher compared to controls, although this was mainly due to one patient with high frequencies of hyperploid sperm. The results indicate that infertility may be a risk factor for chromosomal aneuploidy in spermatozoa. Am. J. Med. Genet. 71:115–121, 1997. © 1997 Wiley-Liss, Inc." @default.
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- W4229692694 date "1997-07-11" @default.
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- W4229692694 title "Incidence of aneuploid spermatozoa among infertile men studied by multicolor fluorescence in situ hybridization" @default.
- W4229692694 doi "https://doi.org/10.1002/(sici)1096-8628(19970711)71:1<115::aid-ajmg21>3.3.co;2-u" @default.
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