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- W4229692971 abstract "THE CLINICAL application of gene therapy could begin as early as next month. As predicted (<i>JAMA</i>. 1990;264:314-317), the Recombinant DNA Committee of the National Institutes of Health has approved, with only one dissenting vote, the protocol intended to correct a rare congenital immune disorder, adenosine deaminase deficiency. The study involves inserting the gene that codes for this missing enzyme into cells obtained from 10 children with the disorder, then returning the cells to the patients. The work would be done at the National Institutes of Health's Clinical Center by W. French Anderson, MD, National Heart, Lung, and Blood Institute, and R. Michael Blaese, MD, National Cancer Institute. Approval still is required, however, from the Food and Drug Administration and from the Acting Director of the National Institutes of Health, William Raub, PhD. Anderson says plans are for the clinical study to begin next month or in November. The committee also" @default.
- W4229692971 created "2022-05-11" @default.
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- W4229692971 date "1990-09-05" @default.
- W4229692971 modified "2023-10-14" @default.
- W4229692971 title "Gene therapy could begin next month" @default.
- W4229692971 doi "https://doi.org/10.1001/jama.264.9.1084" @default.
- W4229692971 hasPublicationYear "1990" @default.
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