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- W4229697926 abstract "Bevacizumab (Avastin) is an approved treatment option by the European Medicines Agency (1) for more than a quarter billion women in the European Union, and despite having its indication withdrawn by the Food and Drug Administration in 2011 is still utilized in clinical trials in the United States (2, 3). We mined published microarray data (4) from the PROMIX trial to understand in an unbiased fashion genes most transcriptionally perturbed by bevacizumab administration and how this interacted with a standard anthracycline and taxane chemotherapeutic regimen, epirubicin and docetaxel. We report here the concomitant induction of AP1 transcription factor subunits JUN, FOS and FOSB in the primary tumors of women with breast cancer treated with bevacizumab, nuclear factors that trigger expression of a host of genes that support the proliferation and growth of cancer (5-13)." @default.
- W4229697926 created "2022-05-11" @default.
- W4229697926 creator A5024900493 @default.
- W4229697926 date "2020-11-20" @default.
- W4229697926 modified "2023-09-23" @default.
- W4229697926 title "Bevacizumab treatment of patients with breast cancer is associated with induction of AP-1 transcription factor subunits." @default.
- W4229697926 doi "https://doi.org/10.31219/osf.io/hbn5m" @default.
- W4229697926 hasPublicationYear "2020" @default.
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