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- W4229698047 abstract "Cell-cycle checkpoint proteins arrest cell division in response to genomic damage and are important in development, but in nondividing cells, these proteins may play a further role in cell maintenance. Olsen et al. show that decreased function of checkpoint proteins in postmitotic, somatic cells of the adult worm triggered increased expression of genes that allow the organism to resist stress. This adaptive response increased organism survival and extended life span by up to 25%. Thus, checkpoint proteins may control whole organism susceptibility to stress, survival, and normal aging.A. Olsen, M. C. Vantipalli, G. J. Lithgow, Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science 312, 1381-1385 (2006). [Abstract] [Full Text]" @default.
- W4229698047 created "2022-05-11" @default.
- W4229698047 date "2006-06-06" @default.
- W4229698047 modified "2023-09-30" @default.
- W4229698047 title "Development, Stress, and Life Span" @default.
- W4229698047 doi "https://doi.org/10.1126/stke.3382006tw195" @default.
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