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- W4229719982 abstract "Using the American College of Rheumatology (ACR) definition, systemic lupus erythematosus (SLE) is diagnosed when at least four criteria are met with a sensitivity and specificity above 95%. These criteria were developed for study purposes to differentiate SLE from other rheumatic diseases. At disease onset, a patient may not meet the ACR threshold, but delaying treatment may be harmful. With SLE prominent in the differential diagnosis of a critically ill patient, physicians must consider the three most common causes of death in lupus patients: lupus crisis, severe infection, and thrombosis. In addition to lupus crisis and infection, the differential diagnosis of acute multisystem disease in a patient with SLE includes catastrophic antiphospholipid syndrome (APS) and thrombotic thrombocytopenic purpura, In critically ill lupus patients, initial treatment may need to be empirically directed at multiple causes until the diagnosis is clear." @default.
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- W4229719982 date "2013-03-15" @default.
- W4229719982 modified "2023-10-17" @default.
- W4229719982 title "A Frayed Knot" @default.
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- W4229719982 doi "https://doi.org/10.1002/9781118483206.ch9" @default.
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