Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229749035> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4229749035 abstract "Macular oedema is one of the complications of retinal vein occlusion. About half of the patients recover spontaneously within 3 to 6 months. There is currently no drug that improves outcome. An intravitreal implant delivering 0.7 mg of dexamethasone has been authorised for the treatment of macular oedema in this setting. Clinical assessment is based on two double-blind randomised trials including a total of 1267 patients, comparing treatment with intravitreal implants delivering about 0.7 mg or 0.35 mg of dexamethasone, versus a sham procedure. Despite a more rapid initial improvement with dexamethasone, the number of patients whose reading ability improved at 6 months did not significantly differ between the groups. A retrospective subgroup analysis raised the possibility that dexamethasone implants may be beneficial in patients with central retinal vein occlusion. The adverse effects of dexamethasone intravitreal implants are the same as those of intraocular steroid injections, including elevated intraocular pressure (25% of patients), cataracts (27%), conjunctival haemorrhage (20%), and ocular pain. In practice, dexamethasone intravitreal implants do not have a positive harm-benefit balance in most patients with macular oedema following retinal vein occlusion. More rapid recovery after central vein occlusion remains to be confirmed. Pending such studies, it is better to avoid using dexamethasone implants. Patients should instead receive ophthalmologic monitoring to detect and manage possible complications, and any risk factors should be treated." @default.
- W4229749035 created "2022-05-11" @default.
- W4229749035 date "2020-02-08" @default.
- W4229749035 modified "2023-10-18" @default.
- W4229749035 title "Dexamethasone Intravitreal Implant" @default.
- W4229749035 doi "https://doi.org/10.32388/ocseg3" @default.
- W4229749035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21751750" @default.
- W4229749035 hasPublicationYear "2020" @default.
- W4229749035 type Work @default.
- W4229749035 citedByCount "0" @default.
- W4229749035 crossrefType "reference-entry" @default.
- W4229749035 hasBestOaLocation W42297490351 @default.
- W4229749035 hasConcept C118487528 @default.
- W4229749035 hasConcept C126322002 @default.
- W4229749035 hasConcept C141071460 @default.
- W4229749035 hasConcept C2776268601 @default.
- W4229749035 hasConcept C2778844676 @default.
- W4229749035 hasConcept C2780347916 @default.
- W4229749035 hasConcept C2780401358 @default.
- W4229749035 hasConcept C2780827179 @default.
- W4229749035 hasConcept C2781092963 @default.
- W4229749035 hasConcept C2781411149 @default.
- W4229749035 hasConcept C2908732032 @default.
- W4229749035 hasConcept C42219234 @default.
- W4229749035 hasConcept C71924100 @default.
- W4229749035 hasConceptScore W4229749035C118487528 @default.
- W4229749035 hasConceptScore W4229749035C126322002 @default.
- W4229749035 hasConceptScore W4229749035C141071460 @default.
- W4229749035 hasConceptScore W4229749035C2776268601 @default.
- W4229749035 hasConceptScore W4229749035C2778844676 @default.
- W4229749035 hasConceptScore W4229749035C2780347916 @default.
- W4229749035 hasConceptScore W4229749035C2780401358 @default.
- W4229749035 hasConceptScore W4229749035C2780827179 @default.
- W4229749035 hasConceptScore W4229749035C2781092963 @default.
- W4229749035 hasConceptScore W4229749035C2781411149 @default.
- W4229749035 hasConceptScore W4229749035C2908732032 @default.
- W4229749035 hasConceptScore W4229749035C42219234 @default.
- W4229749035 hasConceptScore W4229749035C71924100 @default.
- W4229749035 hasLocation W42297490351 @default.
- W4229749035 hasLocation W42297490352 @default.
- W4229749035 hasOpenAccess W4229749035 @default.
- W4229749035 hasPrimaryLocation W42297490351 @default.
- W4229749035 hasRelatedWork W1998389285 @default.
- W4229749035 hasRelatedWork W1999259490 @default.
- W4229749035 hasRelatedWork W2032848331 @default.
- W4229749035 hasRelatedWork W2134055108 @default.
- W4229749035 hasRelatedWork W2427551477 @default.
- W4229749035 hasRelatedWork W2992742423 @default.
- W4229749035 hasRelatedWork W3125628642 @default.
- W4229749035 hasRelatedWork W3137626316 @default.
- W4229749035 hasRelatedWork W770578226 @default.
- W4229749035 hasRelatedWork W2472388845 @default.
- W4229749035 isParatext "false" @default.
- W4229749035 isRetracted "false" @default.
- W4229749035 workType "reference-entry" @default.