FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229750206> ?p ?o ?g. }

• W4229750206 abstract "Abstract Background: During the last decade, there has been a surge towards computational drug repositioning owing to constantly increasing -omics data in the biomedical research field. While numerous existing methods focus on the integration of heterogeneous data to propose candidate drugs, it is still challenging to substantiate their results with mechanistic insights of these candidate drugs. Therefore, there is a need for more innovative and efficient methods which can enable better integration of data and knowledge for drug repositioning. Results: Here, we present a customizable workflow ( PS4DR) which not only integrates high-throughput data such as genome-wide association study (GWAS) data and gene expression signatures from disease and drug perturbations but also takes pathway knowledge into consideration to predict drug candidates for repositioning. We have collected and integrated publicly available GWAS data and gene expression signatures for several diseases and hundreds of FDA-approved drugs or those under clinical trial in this study. Additionally, different pathway databases were used for mechanistic knowledge integration in the workflow. Using this systematic consolidation of data and knowledge, the workflow computes pathway signatures that assist in the prediction of new indications for approved and investigational drugs. Conclusion: We showcase PS4DR with applications demonstrating how this tool can be used for repositioning and identifying new drugs as well as proposing drugs that can simulate disease dysregulations. We were able to validate our workflow by demonstrating its capability to predict FDA-approved drugs for their known indications for several diseases. Further, PS4DR returned many potential drug candidates for repositioning that were backed up by epidemiological evidence extracted from scientific literature. Source code is freely available at https://github.com/ps4dr/ps4dr ." @default.
• W4229750206 created "2022-05-11" @default.
• W4229750206 creator A5003139478 @default.
• W4229750206 creator A5043459521 @default.
• W4229750206 creator A5065488553 @default.
• W4229750206 creator A5087770471 @default.
• W4229750206 date "2020-02-19" @default.
• W4229750206 modified "2023-09-27" @default.
• W4229750206 title "PS4DR: A multimodal workflow for identification and prioritization of drugs based on pathway signatures" @default.
• W4229750206 cites W1663154925 @default.
• W4229750206 cites W1945773664 @default.
• W4229750206 cites W1966165057 @default.
• W4229750206 cites W1968928299 @default.
• W4229750206 cites W1976502930 @default.
• W4229750206 cites W1979188008 @default.
• W4229750206 cites W1979834293 @default.
• W4229750206 cites W1982945330 @default.
• W4229750206 cites W1984789788 @default.
• W4229750206 cites W1988098374 @default.
• W4229750206 cites W1998284148 @default.
• W4229750206 cites W2001502878 @default.
• W4229750206 cites W2002820387 @default.
• W4229750206 cites W2002889122 @default.
• W4229750206 cites W2003738638 @default.
• W4229750206 cites W2009080781 @default.
• W4229750206 cites W2012660986 @default.
• W4229750206 cites W2015808257 @default.
• W4229750206 cites W2020132970 @default.
• W4229750206 cites W2023553115 @default.
• W4229750206 cites W2029442595 @default.
• W4229750206 cites W2030603632 @default.
• W4229750206 cites W2037653131 @default.
• W4229750206 cites W2041934303 @default.
• W4229750206 cites W2044424923 @default.
• W4229750206 cites W2046711070 @default.
• W4229750206 cites W2050130956 @default.
• W4229750206 cites W2050574248 @default.
• W4229750206 cites W2051158121 @default.
• W4229750206 cites W2055619057 @default.
• W4229750206 cites W2077318478 @default.
• W4229750206 cites W2079158266 @default.
• W4229750206 cites W2079554604 @default.
• W4229750206 cites W2080946103 @default.
• W4229750206 cites W2085484758 @default.
• W4229750206 cites W2090808827 @default.
• W4229750206 cites W2093313266 @default.
• W4229750206 cites W2094791588 @default.
• W4229750206 cites W2095032620 @default.
• W4229750206 cites W2098967508 @default.
• W4229750206 cites W2101357408 @default.
• W4229750206 cites W2103335577 @default.
• W4229750206 cites W2103368657 @default.
• W4229750206 cites W2104697581 @default.
• W4229750206 cites W2105014520 @default.
• W4229750206 cites W2106248311 @default.
• W4229750206 cites W2110065044 @default.
• W4229750206 cites W2110687686 @default.
• W4229750206 cites W2116868464 @default.
• W4229750206 cites W2117007075 @default.
• W4229750206 cites W2121001769 @default.
• W4229750206 cites W2121485819 @default.
• W4229750206 cites W2121604817 @default.
• W4229750206 cites W2125808190 @default.
• W4229750206 cites W2129370330 @default.
• W4229750206 cites W2130410032 @default.
• W4229750206 cites W2137632714 @default.
• W4229750206 cites W2138512826 @default.
• W4229750206 cites W2142879323 @default.
• W4229750206 cites W2143251418 @default.
• W4229750206 cites W2145825942 @default.
• W4229750206 cites W2147018385 @default.
• W4229750206 cites W2147241078 @default.
• W4229750206 cites W2149808918 @default.
• W4229750206 cites W2151357092 @default.
• W4229750206 cites W2155157373 @default.
• W4229750206 cites W2162408376 @default.
• W4229750206 cites W2163037808 @default.
• W4229750206 cites W2187351898 @default.
• W4229750206 cites W2264877802 @default.
• W4229750206 cites W2288271162 @default.
• W4229750206 cites W2316959322 @default.
• W4229750206 cites W2462053388 @default.
• W4229750206 cites W2463737032 @default.
• W4229750206 cites W2470708296 @default.
• W4229750206 cites W2524066112 @default.
• W4229750206 cites W2526969304 @default.
• W4229750206 cites W2553642816 @default.
• W4229750206 cites W2557530941 @default.
• W4229750206 cites W2559588208 @default.
• W4229750206 cites W2590029227 @default.
• W4229750206 cites W2610653037 @default.
• W4229750206 cites W2637847957 @default.
• W4229750206 cites W2736912049 @default.
• W4229750206 cites W2749491127 @default.
• W4229750206 cites W2767891136 @default.
• W4229750206 cites W2767914218 @default.
• W4229750206 cites W2807625293 @default.
• W4229750206 cites W2898977037 @default.
• W4229750206 cites W3006508031 @default.
• W4229750206 cites W4233698560 @default.

• next