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- W4229764731 abstract "This chapter provides the basic characteristics, FDA-approved indications, side effects/toxicity, drug interactions, and dosage interactions of the Valtrex (Valacyclovir). Valacyclovir is the valine ester of the nucleoside analog acyclovir. After hydrolysis, it is phosphorylated by thymadine kinase to the active triphosphate form. Acyclovir triphosphate stops replication of herpes viral DNA in three ways: competitive inhibition of viral DNA polymerase, incorporation into and termination of the growing viral DNA chain, and inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral thymidine kinase. Valacyclovir is indicated for the treatment of herpes zoster, the treatment or suppression of genital herpes in immunocompetent individuals, suppression of recurrent genital herpes in HIV-infected individuals and the treatment of cold sores. Valacyclovir doses of eight grams a day have been associated with TTP/HUS in AIDS patients and transplant recipients." @default.
- W4229764731 created "2022-05-11" @default.
- W4229764731 date "2017-08-30" @default.
- W4229764731 modified "2023-10-17" @default.
- W4229764731 title "VALTREX (Valacyclovir)" @default.
- W4229764731 doi "https://doi.org/10.1002/9781119220787.ch183" @default.
- W4229764731 hasPublicationYear "2017" @default.
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