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- W4229775192 abstract "Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating important processes in the brain. To directly visualize the release of 5-HT, we developed a genetically encoded G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB5-HT) sensor with high sensitivity, high selectivity, subsecond kinetics and subcellular resolution. GRAB5-HT detects 5-HT release in multiple physiological and pathological conditions in both flies and mice and provides new insights into the dynamics and mechanisms of 5-HT signaling. PMID: 33821000 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: U01 NS103558 NINDS NIH HHS, United States Grant ID: R01 NS104670 NINDS NIH HHS, United States Grant ID: R01 NS091452 NINDS NIH HHS, United States Grant ID: R01 NS051241" @default.
- W4229775192 created "2022-05-11" @default.
- W4229775192 creator A5044646507 @default.
- W4229775192 date "2021-05-05" @default.
- W4229775192 modified "2023-09-28" @default.
- W4229775192 title "Faculty Opinions recommendation of A genetically encoded sensor for measuring serotonin dynamics." @default.
- W4229775192 doi "https://doi.org/10.3410/f.739874841.793585307" @default.
- W4229775192 hasPublicationYear "2021" @default.
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