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- W4229783670 abstract "The metabolism of the chiral isomers of 35S-labeled fonofos was examined in the house fly and white mouse. Metabolism of the chiral isomers of fonofos oxon also was investigated in the mouse. Little difference in either the rate of penetration or pattern of metabolism was observed between house flies treated with the (R)P and (S)P enantiomers of fonofos. At the higher dosage of 8 mg/kg the less toxic (S)P enantiomer was degraded in mice and eliminated in significantly larger amounts than (R)P-fonofos. However, at the sublethal dosage of 4 mg/kg little difference in degradation and total elimination was observed between the two isomers although the excretion rate appeared to be faster initially with the less toxic enantiomer. Overall, metabolism and excretion of the chiral isomers of both fonofos and fonofos oxon took place more rapidly and to a greater extent with the less toxic enantiomer." @default.
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- W4229783670 date "1978-08-01" @default.
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- W4229783670 title "Studies on the chiral isomers of fonofos and fonofos oxon: III. In vivo metabolism" @default.
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- W4229783670 doi "https://doi.org/10.1016/0048-3575(78)90060-3" @default.
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