Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229803002> ?p ?o ?g. }
- W4229803002 endingPage "791" @default.
- W4229803002 startingPage "784" @default.
- W4229803002 abstract "Abstract Context.—Systemic mastocytosis is characterized by abnormal growth and accumulation of neoplastic mast cells in various organs. The clinical presentation is varied and may include skin rash, symptoms related to release of mast cell mediators, and/or organopathy from involvement of bone, liver, spleen, bowel, or bone marrow. Objective.—To concisely review pathogenesis, disease classification, clinical features, diagnosis, and treatment of mast cell disorders. Data Sources.—Pertinent literature emerging during the last 20 years in the field of mast cell disorders. Conclusions.—The cornerstone of diagnosis is careful bone marrow histologic examination with appropriate immunohistochemical studies. Ancillary tests such as mast cell immunophenotyping, cytogenetic/molecular studies, and serum tryptase levels assist in confirming the diagnosis. Patients with cutaneous disease or with low systemic mast cell burden are generally managed symptomatically. In the patients requiring mast cell cytoreductive therapy, treatment decisions are increasingly being guided by results of molecular studies. Most patients carry the kit D816V mutation and are predicted to be resistant to imatinib mesylate (Gleevec) therapy. In contrast, patients carrying the FIP1L1-PDGFRA mutation achieve complete responses with low-dose imatinib therapy. Other therapeutic options include use of interferon-α, chemotherapy (2-chlorodeoxyadenosine), or novel small molecule tyrosine kinase inhibitors currently in clinical trials." @default.
- W4229803002 created "2022-05-11" @default.
- W4229803002 creator A5016216479 @default.
- W4229803002 creator A5024612499 @default.
- W4229803002 creator A5072463255 @default.
- W4229803002 creator A5073647066 @default.
- W4229803002 creator A5082921715 @default.
- W4229803002 date "2007-05-01" @default.
- W4229803002 modified "2023-10-16" @default.
- W4229803002 title "Systemic Mastocytosis: A Concise Clinical and Laboratory Review" @default.
- W4229803002 cites W1591835698 @default.
- W4229803002 cites W1602040594 @default.
- W4229803002 cites W1682346499 @default.
- W4229803002 cites W171982086 @default.
- W4229803002 cites W1963572129 @default.
- W4229803002 cites W1964710737 @default.
- W4229803002 cites W1965854134 @default.
- W4229803002 cites W1972144397 @default.
- W4229803002 cites W1973112142 @default.
- W4229803002 cites W1974100080 @default.
- W4229803002 cites W1975240950 @default.
- W4229803002 cites W1978563510 @default.
- W4229803002 cites W1980727190 @default.
- W4229803002 cites W1980914876 @default.
- W4229803002 cites W1982418077 @default.
- W4229803002 cites W1982866507 @default.
- W4229803002 cites W1983999811 @default.
- W4229803002 cites W1987162202 @default.
- W4229803002 cites W1987946408 @default.
- W4229803002 cites W1993327121 @default.
- W4229803002 cites W1999304658 @default.
- W4229803002 cites W1999757233 @default.
- W4229803002 cites W2000893535 @default.
- W4229803002 cites W2000903716 @default.
- W4229803002 cites W2004645808 @default.
- W4229803002 cites W2005928149 @default.
- W4229803002 cites W2006647000 @default.
- W4229803002 cites W2006905792 @default.
- W4229803002 cites W2009999550 @default.
- W4229803002 cites W2012245921 @default.
- W4229803002 cites W2012952884 @default.
- W4229803002 cites W2013291652 @default.
- W4229803002 cites W2018012923 @default.
- W4229803002 cites W2019186253 @default.
- W4229803002 cites W2021563625 @default.
- W4229803002 cites W2022236617 @default.
- W4229803002 cites W2024510824 @default.
- W4229803002 cites W2029111664 @default.
- W4229803002 cites W2031012387 @default.
- W4229803002 cites W2032542447 @default.
- W4229803002 cites W2033388083 @default.
- W4229803002 cites W2033550167 @default.
- W4229803002 cites W2036714385 @default.
- W4229803002 cites W2038961612 @default.
- W4229803002 cites W2044457674 @default.
- W4229803002 cites W2044833992 @default.
- W4229803002 cites W2046632940 @default.
- W4229803002 cites W2049447930 @default.
- W4229803002 cites W2050762664 @default.
- W4229803002 cites W2058481481 @default.
- W4229803002 cites W2060197923 @default.
- W4229803002 cites W2064244980 @default.
- W4229803002 cites W2066098834 @default.
- W4229803002 cites W2066288259 @default.
- W4229803002 cites W2067545549 @default.
- W4229803002 cites W2067847647 @default.
- W4229803002 cites W2068970590 @default.
- W4229803002 cites W2072457855 @default.
- W4229803002 cites W2075428599 @default.
- W4229803002 cites W2077078463 @default.
- W4229803002 cites W2077338620 @default.
- W4229803002 cites W2077810015 @default.
- W4229803002 cites W2077945888 @default.
- W4229803002 cites W2078398386 @default.
- W4229803002 cites W2081007495 @default.
- W4229803002 cites W2082619262 @default.
- W4229803002 cites W2082764544 @default.
- W4229803002 cites W2085516033 @default.
- W4229803002 cites W2087935715 @default.
- W4229803002 cites W2090502222 @default.
- W4229803002 cites W2095226581 @default.
- W4229803002 cites W2097722688 @default.
- W4229803002 cites W2100989666 @default.
- W4229803002 cites W2101164739 @default.
- W4229803002 cites W2107108810 @default.
- W4229803002 cites W2107590922 @default.
- W4229803002 cites W2107944726 @default.
- W4229803002 cites W2111914345 @default.
- W4229803002 cites W2111935453 @default.
- W4229803002 cites W2113793740 @default.
- W4229803002 cites W2115823813 @default.
- W4229803002 cites W2116768113 @default.
- W4229803002 cites W2119323720 @default.
- W4229803002 cites W2122605148 @default.
- W4229803002 cites W2130710121 @default.
- W4229803002 cites W2135105253 @default.
- W4229803002 cites W2135429827 @default.
- W4229803002 cites W2143438679 @default.