Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229803016> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4229803016 endingPage "338" @default.
- W4229803016 startingPage "329" @default.
- W4229803016 abstract "From functional studies with propylbenzilylcholine mustard (PrBCM), we reported that there coexist PrBCM-sensitive and PrBCM-resistant muscarinic cholinoceptor mechanisms in guinea pig taenia caecum. We investigated the interrelationship between these two cholinoceptor mechanisms using an in vitro receptor binding assay with [3H]quinuclidinyl benzilate (QNB) and [3H]PrBCM. Pretreatment of the muscle strips with 300 nM PrBCM (in vivo alkylation) for 10-50 min resulted in progressive decreases of the number of the maximum [3H]QNB binding sites. However, a prolongation of the period of in vivo alkylation up to 90 min was accompanied with no further loss in the binding sites. Under these conditions, there is no significant change in the affinity of [3H]QNB for the binding sites. The concentration of carbachol required to displace 50% of the bound [3H]QNB was larger in membranes obtained from the tissues that had been alkylated in vivo with PrBCM for 50 min than that from control strips, but was not altered when the pretreatment with the drug was carried out after homogenization (in vitro alkylation). When GTP was added during in vitro alkylation, the affinity of carbachol was lower than that in control membranes, as observed when in vivo alkylation was carried out. In the presence of guanine nucleotide, PrBCM thus appears to recognize two distinct populations or states of muscarinic receptors." @default.
- W4229803016 created "2022-05-11" @default.
- W4229803016 creator A5002957311 @default.
- W4229803016 creator A5008213951 @default.
- W4229803016 creator A5014685914 @default.
- W4229803016 creator A5030726308 @default.
- W4229803016 date "1991-01-01" @default.
- W4229803016 modified "2023-09-28" @default.
- W4229803016 title "Guanosine 5’-Triphosphate Converts Some Populations of Propylbenzilylcholine Mustard-Sensitive Muscarinic Cholinoceptor Sites to Sites Resistant to the Drug in Intestinal Smooth Muscle" @default.
- W4229803016 cites W1534712484 @default.
- W4229803016 cites W1775749144 @default.
- W4229803016 cites W1978745809 @default.
- W4229803016 cites W1979334541 @default.
- W4229803016 cites W2002494433 @default.
- W4229803016 cites W2002500227 @default.
- W4229803016 cites W2004371728 @default.
- W4229803016 cites W2004496422 @default.
- W4229803016 cites W2025609673 @default.
- W4229803016 cites W2025732540 @default.
- W4229803016 cites W2027076649 @default.
- W4229803016 cites W2042403615 @default.
- W4229803016 cites W2052673887 @default.
- W4229803016 cites W2077066545 @default.
- W4229803016 cites W2080335457 @default.
- W4229803016 doi "https://doi.org/10.1016/s0021-5198(19)39934-2" @default.
- W4229803016 hasPublicationYear "1991" @default.
- W4229803016 type Work @default.
- W4229803016 citedByCount "1" @default.
- W4229803016 crossrefType "journal-article" @default.
- W4229803016 hasAuthorship W4229803016A5002957311 @default.
- W4229803016 hasAuthorship W4229803016A5008213951 @default.
- W4229803016 hasAuthorship W4229803016A5014685914 @default.
- W4229803016 hasAuthorship W4229803016A5030726308 @default.
- W4229803016 hasBestOaLocation W42298030161 @default.
- W4229803016 hasConcept C104317684 @default.
- W4229803016 hasConcept C107824862 @default.
- W4229803016 hasConcept C12554922 @default.
- W4229803016 hasConcept C150903083 @default.
- W4229803016 hasConcept C161790260 @default.
- W4229803016 hasConcept C164361826 @default.
- W4229803016 hasConcept C170493617 @default.
- W4229803016 hasConcept C185592680 @default.
- W4229803016 hasConcept C202751555 @default.
- W4229803016 hasConcept C207001950 @default.
- W4229803016 hasConcept C2778301229 @default.
- W4229803016 hasConcept C2778988552 @default.
- W4229803016 hasConcept C33789571 @default.
- W4229803016 hasConcept C512185932 @default.
- W4229803016 hasConcept C55493867 @default.
- W4229803016 hasConcept C86803240 @default.
- W4229803016 hasConcept C98274493 @default.
- W4229803016 hasConceptScore W4229803016C104317684 @default.
- W4229803016 hasConceptScore W4229803016C107824862 @default.
- W4229803016 hasConceptScore W4229803016C12554922 @default.
- W4229803016 hasConceptScore W4229803016C150903083 @default.
- W4229803016 hasConceptScore W4229803016C161790260 @default.
- W4229803016 hasConceptScore W4229803016C164361826 @default.
- W4229803016 hasConceptScore W4229803016C170493617 @default.
- W4229803016 hasConceptScore W4229803016C185592680 @default.
- W4229803016 hasConceptScore W4229803016C202751555 @default.
- W4229803016 hasConceptScore W4229803016C207001950 @default.
- W4229803016 hasConceptScore W4229803016C2778301229 @default.
- W4229803016 hasConceptScore W4229803016C2778988552 @default.
- W4229803016 hasConceptScore W4229803016C33789571 @default.
- W4229803016 hasConceptScore W4229803016C512185932 @default.
- W4229803016 hasConceptScore W4229803016C55493867 @default.
- W4229803016 hasConceptScore W4229803016C86803240 @default.
- W4229803016 hasConceptScore W4229803016C98274493 @default.
- W4229803016 hasIssue "3" @default.
- W4229803016 hasLocation W42298030161 @default.
- W4229803016 hasOpenAccess W4229803016 @default.
- W4229803016 hasPrimaryLocation W42298030161 @default.
- W4229803016 hasRelatedWork W1991678804 @default.
- W4229803016 hasRelatedWork W2025732540 @default.
- W4229803016 hasRelatedWork W2075338952 @default.
- W4229803016 hasRelatedWork W2075552151 @default.
- W4229803016 hasRelatedWork W2086853855 @default.
- W4229803016 hasRelatedWork W2367637308 @default.
- W4229803016 hasRelatedWork W2391243492 @default.
- W4229803016 hasRelatedWork W2433311123 @default.
- W4229803016 hasRelatedWork W2622510373 @default.
- W4229803016 hasRelatedWork W2953758866 @default.
- W4229803016 hasVolume "55" @default.
- W4229803016 isParatext "false" @default.
- W4229803016 isRetracted "false" @default.
- W4229803016 workType "article" @default.