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- W4229803990 abstract "Fragmented sarcoplasmic reticulum fraction (SR) was prepared from the ventricle of canine heart, and the effect of diltiazem on its Ca2+ binding and Ca2+ release was examined by centrifugation and filtration methods using 45Ca. Cardiac SR bound 45-55 nmoles/mg of Ca ions in the presence of Mg-ATP, Diltiazem in concentrations up to 10-4 M had little effect on the Ca2+ binding of SR. The membrane of cardiac SR was “depolarized” by either changing propionate to chloride (anionic) or potassium to Tris (hydroxymethyl) aminomethane (Tris) (cationic). About 12% of the maximum Ca2+ bound to the SR was released by cationic “depolarization”, but no Ca2+ was released by anionic “depolarization”. The Ca2+ release induced by the cationic “depolarization” was inhibited by diltiazem, and the inhibitory effect of diltiazem on the Ca2+ release was dependent on the incubation time, Incubation of the SR with 3×10-6 M diltiazem for 30 sec almost completely inhibited the release of Ca2+, while incubation with 3×10-7 M diltiazem incompletely inhibited the Ca2+ release. About 20% of the maximum Ca2+ bound to the SR was released by the addition of 5.1 mM caffeine. The Ca2+ release induced by caffeine was inhibited by increasing the concentration of MgCl2 from 5 to 10 mM, but was not inhibited by 10 mM procaine. An increase of ATP concentration accelerated the time course of the caffeine-induced release of Ca2+ from the SR and subsequent rebinding of Ca2+. Diltiazem up to 10-5 M had no effect on the caffeine-induced Ca2+ release. These findings clearly indicate that diltiazem inhibits the “depolarization”-induced Ca2+ release from cardiac sarcoplasmic reticulum." @default.
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- W4229803990 date "1983-01-01" @default.
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- W4229803990 title "EFFECT OF DILTIAZEM ON THE RELEASE OF CALCIUM FROM THE CANINE FRAGMENTED CARDIAC SARCOPLASMIC RETICULUM" @default.
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- W4229803990 doi "https://doi.org/10.1016/s0021-5198(19)52444-1" @default.
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