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- W4229812903 abstract "This chapter first focuses on the following metabolic disorders: inherited metabolic disorders, including lysosomal storage disorders, neuronal ceroid lipofuscinosis, and galactosialidosis; and acquired metabolic disorders, including thiamine deficiency, hepatic encephalopathy, osmotic demyelination syndrome, and peri-ictal encephalopathy. Lysosomal storage disorders are a group of more than 50 rare inherited diseases characterized by failure of lysosomes to metabolize lipids or glycoproteins. Thiamine deficiency is rare and usually results from animals being fed commercial or noncommercial diets deficient in thiamine. The chapter then focuses on toxic disorders, including radiation-induced brain injury and metronidazole toxicity, and finally on degenerative disorders, namely, age-related degeneration and neurodegenerative disorders. Neurotoxic effects of brain irradiation can be divided into an acute response, characterized by reversible vasogenic edema; an early delayed response, involving edema and demyelination; and a late delayed response that includes irreversible vascular changes and necrotizing leukoencephalopathy." @default.
- W4229812903 created "2022-05-11" @default.
- W4229812903 date "2015-04-29" @default.
- W4229812903 modified "2023-09-23" @default.
- W4229812903 title "Metabolic, toxic, and degenerative disorders" @default.
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- W4229812903 doi "https://doi.org/10.1002/9781119421399.ch16" @default.
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