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• W4229815226 endingPage "11885" @default.
• W4229815226 startingPage "11882" @default.
• W4229815226 abstract "Sequence inversion in G-rich DNA from 5′→3′ to 3′→5′ exerts a substantial effect on the number of structures formed, while the type of G-quadruplex fold is in fact determined by the presence of K+ or Na+ ions. The melting temperatures of G-quadruplexes adopted by oligonucleotides with sequences in the 5′→3′ direction are higher than those of their 3′→5′ counterparts with both KCl and NaCl. CD, UV, and NMR spectroscopy demonstrates the importance of primary sequence for the structural diversity of G-quadruplexes. The changes introduced by mere sequence reversal of the G-rich DNA segment have a substantial impact on the polymorphic nature of the resulting G-quadruplexes and their potential physiological roles. The insights resulting from this study should enable extension of the empirical rules for the prediction of G-quadruplex topology." @default.
• W4229815226 created "2022-05-11" @default.
• W4229815226 creator A5034804466 @default.
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• W4229815226 date "2015-08-12" @default.
• W4229815226 modified "2023-10-13" @default.
• W4229815226 title "The Effect of DNA Sequence Directionality on G-Quadruplex Folding" @default.
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• W4229815226 doi "https://doi.org/10.1002/ange.201505348" @default.
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