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- W4229820914 abstract "Background. Diseases with low-grade inflammation perturb endothelial function. We investigated whether preterm premature rupture of membranes (PPROM) is associated with endothelial dysfunction, as assessed by the levels of endothelium-derived nitric oxide metabolites (NOx) and E-selectin in maternal serum. Methods. The concentrations of NOx and E-selectin were measured in 32 pregnant women with PPROM and in 27 healthy gestational age-matched control women. The grade of inflammation was estimated by measuring serum C-reactive protein (CRP) and interleukin-6 (IL-6) concentrations. Results. NOx and E-selectin concentrations were not different in PPROM patients as compared to controls. In 17 patients with PPROM, CRP rose above 12 mg/L. In this group, IL-6 concentration was significantly higher than among controls, but concentrations of NOx and E-selectin remained unaltered. There was a negative correlation between the levels of NOx, CRP and IL-6 and the interval from PPROM to delivery. The levels of NOx correlated positively with those of IL-6. Conclusions. PPROM, with or without CRP and IL-6 surges, does not affect endothelial function markedly, as judged from the unaltered concentrations of NOx and E-selectin in maternal serum." @default.
- W4229820914 created "2022-05-11" @default.
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- W4229820914 date "2003-01-01" @default.
- W4229820914 modified "2023-09-30" @default.
- W4229820914 title "Serum nitric oxide metabolites and E-selectin in preterm premature rupture of membranes" @default.
- W4229820914 doi "https://doi.org/10.1080/j.1600-0412.2003.00166.x" @default.
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