Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229848103> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4229848103 abstract "Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We found that human type 1 diabetic (T1D) and non-obese diabetic (NOD) mouse islets show reduced β-cell STX4 expression, consistent with decreased STX4 expression as a potential driver of T1D phenotypes. To test this hypothesis, we generated inducible β-cell-specific STX4-expressing NOD mice (NOD-iβSTX4).<b> </b>Of NOD-iβSTX4 mice, 73% had sustained normoglycemia versus <20% of control NOD (NOD-Ctrl) mice, by 25 weeks of age. At 12 weeks of age, prior to diabetes conversion, NOD-iβSTX4 mice demonstrated superior whole-body glucose tolerance and β-cell glucose responsiveness than NOD-Ctrl mice. Higher β-cell mass and reduced β-cell apoptosis were also detected in NOD-iβSTX4 pancreata compared with those of NOD-Ctrl mice. Single-cell RNA‐sequencing revealed that islets from NOD-iβSTX4 had markedly reduced IFNƔ signaling and TNFα signaling via NF-ĸB in islet β-cells, including reduced expression of the chemokine CCL5; CD4<sup>+</sup> Treg cells were also enriched in NOD-iβSTX4 islets. These results provide a deeper mechanistic understanding of STX4 function in β-cell protection and warrant further investigation of STX4 enrichment as a strategy to reverse or prevent T1D in humans or protect β-cell grafts." @default.
- W4229848103 created "2022-05-11" @default.
- W4229848103 creator A5007210533 @default.
- W4229848103 creator A5009459379 @default.
- W4229848103 creator A5023576332 @default.
- W4229848103 creator A5045317949 @default.
- W4229848103 creator A5048043338 @default.
- W4229848103 creator A5056729991 @default.
- W4229848103 creator A5060371594 @default.
- W4229848103 creator A5081864075 @default.
- W4229848103 creator A5083330354 @default.
- W4229848103 date "2021-09-23" @default.
- W4229848103 modified "2023-09-28" @default.
- W4229848103 title "Syntaxin 4 Eenrichment in β-cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice" @default.
- W4229848103 doi "https://doi.org/10.2337/figshare.16613851" @default.
- W4229848103 hasPublicationYear "2021" @default.
- W4229848103 type Work @default.
- W4229848103 citedByCount "0" @default.
- W4229848103 crossrefType "posted-content" @default.
- W4229848103 hasAuthorship W4229848103A5007210533 @default.
- W4229848103 hasAuthorship W4229848103A5009459379 @default.
- W4229848103 hasAuthorship W4229848103A5023576332 @default.
- W4229848103 hasAuthorship W4229848103A5045317949 @default.
- W4229848103 hasAuthorship W4229848103A5048043338 @default.
- W4229848103 hasAuthorship W4229848103A5056729991 @default.
- W4229848103 hasAuthorship W4229848103A5060371594 @default.
- W4229848103 hasAuthorship W4229848103A5081864075 @default.
- W4229848103 hasAuthorship W4229848103A5083330354 @default.
- W4229848103 hasBestOaLocation W42298481031 @default.
- W4229848103 hasConcept C126322002 @default.
- W4229848103 hasConcept C13373296 @default.
- W4229848103 hasConcept C134018914 @default.
- W4229848103 hasConcept C1491633281 @default.
- W4229848103 hasConcept C165220095 @default.
- W4229848103 hasConcept C203014093 @default.
- W4229848103 hasConcept C2778013207 @default.
- W4229848103 hasConcept C2779306644 @default.
- W4229848103 hasConcept C55493867 @default.
- W4229848103 hasConcept C555293320 @default.
- W4229848103 hasConcept C55851684 @default.
- W4229848103 hasConcept C71924100 @default.
- W4229848103 hasConcept C86803240 @default.
- W4229848103 hasConcept C8891405 @default.
- W4229848103 hasConceptScore W4229848103C126322002 @default.
- W4229848103 hasConceptScore W4229848103C13373296 @default.
- W4229848103 hasConceptScore W4229848103C134018914 @default.
- W4229848103 hasConceptScore W4229848103C1491633281 @default.
- W4229848103 hasConceptScore W4229848103C165220095 @default.
- W4229848103 hasConceptScore W4229848103C203014093 @default.
- W4229848103 hasConceptScore W4229848103C2778013207 @default.
- W4229848103 hasConceptScore W4229848103C2779306644 @default.
- W4229848103 hasConceptScore W4229848103C55493867 @default.
- W4229848103 hasConceptScore W4229848103C555293320 @default.
- W4229848103 hasConceptScore W4229848103C55851684 @default.
- W4229848103 hasConceptScore W4229848103C71924100 @default.
- W4229848103 hasConceptScore W4229848103C86803240 @default.
- W4229848103 hasConceptScore W4229848103C8891405 @default.
- W4229848103 hasLocation W42298481031 @default.
- W4229848103 hasLocation W42298481032 @default.
- W4229848103 hasLocation W42298481033 @default.
- W4229848103 hasOpenAccess W4229848103 @default.
- W4229848103 hasPrimaryLocation W42298481031 @default.
- W4229848103 hasRelatedWork W1579075587 @default.
- W4229848103 hasRelatedWork W1850629359 @default.
- W4229848103 hasRelatedWork W1973049774 @default.
- W4229848103 hasRelatedWork W1992066058 @default.
- W4229848103 hasRelatedWork W2012430287 @default.
- W4229848103 hasRelatedWork W2031301348 @default.
- W4229848103 hasRelatedWork W2064538767 @default.
- W4229848103 hasRelatedWork W2069827981 @default.
- W4229848103 hasRelatedWork W2095179743 @default.
- W4229848103 hasRelatedWork W2119411112 @default.
- W4229848103 isParatext "false" @default.
- W4229848103 isRetracted "false" @default.
- W4229848103 workType "article" @default.