Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229885735> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4229885735 endingPage "S506" @default.
- W4229885735 startingPage "S500" @default.
- W4229885735 abstract "Patients may be intolerant of zidovudine for several reasons, the most prominent being hematologic toxicity. In vitro studies demonstrate that zidovudine is toxic to the myeloid and erythroid precursors in the bone marrow; at concentrations of zidovudine near those associated with the optimal antiviral effect in vitro, the proliferative capability of these progenitor cellsis reduced 50%–70%. The clinicalmanifestations of anemia and leukopenia generally are time- and dose-dependent. Strategies for alleviating the hematologic toxicity of zidovudine include the use of hematopoietic growth factors, such as erythropoietin, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor. Myopathy, a recently recognized toxic effect of zidovudine, also appears to be time-dependent. Patients often complain of muscle weakness and discomfort and exhibit an associated elevation in creatine phosphokinase level; dose reduction or discontinuation of therapy generally is required. Some patients have experienced high fever, nausea, and vomiting; however, these effects are unusual and of unclear etiology.The substantial proportion of patients with AIDS or AIDS-related complex receiving zidovudine who experience hematologic or muscular toxicity may benefit from treatment with new antiviral agents, such as dideoxyinosine, with toxicity profiles different from that of zidovudine." @default.
- W4229885735 created "2022-05-11" @default.
- W4229885735 creator A5073353369 @default.
- W4229885735 date "1990-07-01" @default.
- W4229885735 modified "2023-10-11" @default.
- W4229885735 title "Zidovudine Intolerance" @default.
- W4229885735 doi "https://doi.org/10.1093/clinids/12.supplement_5.s500" @default.
- W4229885735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2201071" @default.
- W4229885735 hasPublicationYear "1990" @default.
- W4229885735 type Work @default.
- W4229885735 citedByCount "29" @default.
- W4229885735 countsByYear W42298857352017 @default.
- W4229885735 countsByYear W42298857352018 @default.
- W4229885735 countsByYear W42298857352023 @default.
- W4229885735 crossrefType "journal-article" @default.
- W4229885735 hasAuthorship W4229885735A5073353369 @default.
- W4229885735 hasConcept C126322002 @default.
- W4229885735 hasConcept C203014093 @default.
- W4229885735 hasConcept C2778248108 @default.
- W4229885735 hasConcept C2780007613 @default.
- W4229885735 hasConcept C2780216070 @default.
- W4229885735 hasConcept C2780727368 @default.
- W4229885735 hasConcept C2780873365 @default.
- W4229885735 hasConcept C2781440808 @default.
- W4229885735 hasConcept C29730261 @default.
- W4229885735 hasConcept C3013748606 @default.
- W4229885735 hasConcept C71924100 @default.
- W4229885735 hasConcept C90924648 @default.
- W4229885735 hasConcept C98274493 @default.
- W4229885735 hasConceptScore W4229885735C126322002 @default.
- W4229885735 hasConceptScore W4229885735C203014093 @default.
- W4229885735 hasConceptScore W4229885735C2778248108 @default.
- W4229885735 hasConceptScore W4229885735C2780007613 @default.
- W4229885735 hasConceptScore W4229885735C2780216070 @default.
- W4229885735 hasConceptScore W4229885735C2780727368 @default.
- W4229885735 hasConceptScore W4229885735C2780873365 @default.
- W4229885735 hasConceptScore W4229885735C2781440808 @default.
- W4229885735 hasConceptScore W4229885735C29730261 @default.
- W4229885735 hasConceptScore W4229885735C3013748606 @default.
- W4229885735 hasConceptScore W4229885735C71924100 @default.
- W4229885735 hasConceptScore W4229885735C90924648 @default.
- W4229885735 hasConceptScore W4229885735C98274493 @default.
- W4229885735 hasIssue "Supplement_5" @default.
- W4229885735 hasLocation W42298857351 @default.
- W4229885735 hasLocation W42298857352 @default.
- W4229885735 hasOpenAccess W4229885735 @default.
- W4229885735 hasPrimaryLocation W42298857351 @default.
- W4229885735 hasRelatedWork W1511187821 @default.
- W4229885735 hasRelatedWork W2163184063 @default.
- W4229885735 hasRelatedWork W2317362457 @default.
- W4229885735 hasRelatedWork W2357273538 @default.
- W4229885735 hasRelatedWork W2361544313 @default.
- W4229885735 hasRelatedWork W2367148332 @default.
- W4229885735 hasRelatedWork W2392383546 @default.
- W4229885735 hasRelatedWork W2396323476 @default.
- W4229885735 hasRelatedWork W2419081241 @default.
- W4229885735 hasRelatedWork W3149210031 @default.
- W4229885735 hasVolume "12" @default.
- W4229885735 isParatext "false" @default.
- W4229885735 isRetracted "false" @default.
- W4229885735 workType "article" @default.