Matches in SemOpenAlex for { <https://semopenalex.org/work/W4229896543> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4229896543 endingPage "253" @default.
- W4229896543 startingPage "253" @default.
- W4229896543 abstract "Exposure to environmental tobacco smoke (ETS), which is largely composed of the sidestream cigarette smoke, has been implicated in increased incidence of cancer among nonsmokers. The present study was conducted to compare the potential of mainstream and sidestream cigarette smoke to induce DNA adducts in mice. Groups of female C57Bl and DBA mice were exposed twice daily for 65-70 weeks to mainstream or sidestream smoke from the University of Kentucky reference cigarettes (2R1) in a nose-only exposure system. Animals received a total particulate matter dose of about 16 and 6 mg/kg body weight/exposure and exhibited blood carboxyhemoglobin levels of about 16 and 34%, for mainstream and sidestream smoke-exposed groups, respectively. Pulmonary aryl hydrocarbon hydroxylase (AHH) activity was induced by about 2- to 3-fold in both mainstream and sidestream groups of C57Bl and in mainstream smoke-exposed group of DBA mice, but not in sidestream smoke-exposed DBA mice. An analysis of total DNA adduct levels by the 32P-postlabeling assay showed a significant (12- to 25-fold) increase in the magnitude of preexisting lung DNA adducts in both mainstream and sidestream smoke-exposed C57Bl and DBA mice. Smoke exposures did not affect the total preexisting DNA adducts in liver of either strain. It is concluded that both mainstream and sidestream smoke are capable of enhancing preexisting DNA adducts in the lungs of chronically smoke-exposed mice." @default.
- W4229896543 created "2022-05-11" @default.
- W4229896543 creator A5026282888 @default.
- W4229896543 creator A5027463478 @default.
- W4229896543 creator A5035745030 @default.
- W4229896543 creator A5065164142 @default.
- W4229896543 date "1993-03-01" @default.
- W4229896543 modified "2023-09-26" @default.
- W4229896543 title "Mainstream and Sidestream Cigarette Smoke-Induced DNA Adducts in C7Bl and DBA Mice" @default.
- W4229896543 doi "https://doi.org/10.2307/3431494" @default.
- W4229896543 hasPublicationYear "1993" @default.
- W4229896543 type Work @default.
- W4229896543 citedByCount "2" @default.
- W4229896543 crossrefType "journal-article" @default.
- W4229896543 hasAuthorship W4229896543A5026282888 @default.
- W4229896543 hasAuthorship W4229896543A5027463478 @default.
- W4229896543 hasAuthorship W4229896543A5035745030 @default.
- W4229896543 hasAuthorship W4229896543A5065164142 @default.
- W4229896543 hasBestOaLocation W42298965431 @default.
- W4229896543 hasConcept C114246631 @default.
- W4229896543 hasConcept C129990765 @default.
- W4229896543 hasConcept C142724271 @default.
- W4229896543 hasConcept C143425029 @default.
- W4229896543 hasConcept C16685009 @default.
- W4229896543 hasConcept C178790620 @default.
- W4229896543 hasConcept C185592680 @default.
- W4229896543 hasConcept C2776281542 @default.
- W4229896543 hasConcept C2778355491 @default.
- W4229896543 hasConcept C2993351451 @default.
- W4229896543 hasConcept C33070731 @default.
- W4229896543 hasConcept C552990157 @default.
- W4229896543 hasConcept C55493867 @default.
- W4229896543 hasConcept C58874564 @default.
- W4229896543 hasConcept C71924100 @default.
- W4229896543 hasConcept C86803240 @default.
- W4229896543 hasConcept C98274493 @default.
- W4229896543 hasConceptScore W4229896543C114246631 @default.
- W4229896543 hasConceptScore W4229896543C129990765 @default.
- W4229896543 hasConceptScore W4229896543C142724271 @default.
- W4229896543 hasConceptScore W4229896543C143425029 @default.
- W4229896543 hasConceptScore W4229896543C16685009 @default.
- W4229896543 hasConceptScore W4229896543C178790620 @default.
- W4229896543 hasConceptScore W4229896543C185592680 @default.
- W4229896543 hasConceptScore W4229896543C2776281542 @default.
- W4229896543 hasConceptScore W4229896543C2778355491 @default.
- W4229896543 hasConceptScore W4229896543C2993351451 @default.
- W4229896543 hasConceptScore W4229896543C33070731 @default.
- W4229896543 hasConceptScore W4229896543C552990157 @default.
- W4229896543 hasConceptScore W4229896543C55493867 @default.
- W4229896543 hasConceptScore W4229896543C58874564 @default.
- W4229896543 hasConceptScore W4229896543C71924100 @default.
- W4229896543 hasConceptScore W4229896543C86803240 @default.
- W4229896543 hasConceptScore W4229896543C98274493 @default.
- W4229896543 hasLocation W42298965431 @default.
- W4229896543 hasLocation W42298965432 @default.
- W4229896543 hasOpenAccess W4229896543 @default.
- W4229896543 hasPrimaryLocation W42298965431 @default.
- W4229896543 hasRelatedWork W1042255772 @default.
- W4229896543 hasRelatedWork W2021067475 @default.
- W4229896543 hasRelatedWork W2075516008 @default.
- W4229896543 hasRelatedWork W2094593685 @default.
- W4229896543 hasRelatedWork W2137089968 @default.
- W4229896543 hasRelatedWork W2179359531 @default.
- W4229896543 hasRelatedWork W2186720847 @default.
- W4229896543 hasRelatedWork W2342549181 @default.
- W4229896543 hasRelatedWork W2370274240 @default.
- W4229896543 hasRelatedWork W3148100079 @default.
- W4229896543 hasVolume "99" @default.
- W4229896543 isParatext "false" @default.
- W4229896543 isRetracted "false" @default.
- W4229896543 workType "article" @default.