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- W4230055601 abstract "N-Methyl-N′-nitro-N-nitrosoguanidine (nitrosoguanidine) causes an unexpectedly high frequency of closely linked double mutants because of its specificity for chromosome regions in replication. Low nitrosoguanidine concentrations (1 μg/ml) in liquid cultures allow replication at the normal rate and are mutagenic. It was expected that mutations would be spread over the chromosome as it replicated, but a high frequency of closely linked double mutants was found.If a thymine auxotroph is grown in the presence of 5-bromodeoxyuridine (BUdR) and nitrosoguanidine, then exposed to 313-nm radiation (which destroys BUdR-substituted DNA), the mutation frequency is much higher among survivors than among non-irradiated cells. It is concluded that nitrosoguanidine inhibits DNA replication in a small fraction of the population and that mutations are induced in that same fraction.Nitrosoguanidine treatment leads to a high frequency of closely linked double mutants under all known conditions." @default.
- W4230055601 created "2022-05-11" @default.
- W4230055601 date "1973-08-01" @default.
- W4230055601 modified "2023-10-18" @default.
- W4230055601 title "Mutagenic response of known carcinogens" @default.
- W4230055601 doi "https://doi.org/10.1016/0165-1161(73)90235-5" @default.
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