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- W4230109097 abstract "Abstract Echinomycin is a nonribosomal depsipeptide natural product with a range of interesting bioactivities that make it an important target for drug discovery and development. It contains a thioacetal bridge, a unique chemical motif derived from the disulfide bond of its precursor antibiotic triostin A by the action of an S ‐adenosyl‐ L ‐methionine‐dependent methyltransferase, Ecm18. The crystal structure of Ecm18 in complex with its reaction products S ‐adenosyl‐ L ‐homocysteine and echinomycin was determined at 1.50 Å resolution. Phasing was achieved using a new molecular replacement package called AMPLE, which automatically derives search models from structure predictions based on ab initio protein modelling. Structural analysis indicates that a combination of proximity effects, medium effects, and catalysis by strain drives the unique transformation of the disulfide bond into the thioacetal linkage." @default.
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- W4230109097 date "2013-12-02" @default.
- W4230109097 modified "2023-10-18" @default.
- W4230109097 title "Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis" @default.
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- W4230109097 doi "https://doi.org/10.1002/ange.201307404" @default.
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