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- W4230142382 abstract "AbstractAll radiolabeled compounds used for the purpose of diagnosis or therapy in general, have been defined as radiopharmaceuticals by the FDA. The term, radiolabeled molecular imaging probe (RMIP), however, is specifically used to visualize, characterize, and measure biological processes in living systems. This chapter provides a broad overview of different categories of molecular imaging probes and the selection of an appropriate radionuclide to develop radiopharmaceuticals for PET and SPECT. Also, developing a specific RMIP involves careful design of the structural requirements in a molecule in order to optimize target specificity, and at the same time optimize the pharmacokinetic and pharmacodynamic behavior. While the physicochemical properties such as size, charge, solubility, lipophilicity, and specific activity are very important design criteria, factors such as rapid metabolism, plasma protein binding and non-specific binding in non-target tissues are not desirable for optimal in vivo behavior of the imaging agent. The significance of some of these important design features is explained using specific examples. Finally, the role of automated synthesis modules and microfluidic systems is briefly discussed at the end.KeywordsMolecular ImagingPlasma Protein BindingThymidine PhosphorylaseThymidine AnalogAromatic Amino Acid DecarboxylaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W4230142382 created "2022-05-11" @default.
- W4230142382 date "2009-01-01" @default.
- W4230142382 modified "2023-09-30" @default.
- W4230142382 title "Radiopharmaceuticals" @default.
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- W4230142382 doi "https://doi.org/10.1007/978-3-540-76735-0_9" @default.
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