Matches in SemOpenAlex for { <https://semopenalex.org/work/W4230147765> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4230147765 abstract "Abstract BACKGROUND : As opioid use disorder (OUD) incidence and its associated deaths continue to persist at elevated rates, the development of novel treatment modalities is warranted. Recent strides in this therapeutic area include novel anti-opioid vaccine approaches. This work compares logistical and ethical considerations surrounding currently available interventions for opioid use disorder with an anti-opioid vaccine approach. METHODS : The opinions of student pharmacists and practicing pharmacists assessing knowledge, perceptions, and attitudes toward current and future OUD management strategies were characterized using a staged, multi-modal research approach incorporating a focus group, pilot survey development and refinement, and final survey deployment. Survey responses were assessed using one- and two-way parametric and non-parametric analyses where appropriate, and multi-dimensional matrix profiles were compared using z-tests following an exhaustive combinatorial sum of differences calculation between items within each compared matrix. RESULTS : Focus group content analysis revealed a high level of agreeableness among participants regarding anti-opioid vaccine technology and a sense of shared ownership regarding solutions to the opioid epidemic at large. Pilot survey results demonstrated subject ability to consider both pragmatic and ethical considerations related to current therapeutics and novel interventions in a single instrument, with high endurance amongst engaged subjects. Access inequality was the most concerning ethical consideration identified for anti-opioid vaccines. Support for anti-opioid vaccine implementation across various clinical scenarios was strongest for voluntary use amongst individuals in recovery, and lowest for mandatory use in at-risk individuals. CONCLUSIONS : Ethical and logistical concerns surrounding anti-opioid vaccines were largely similar to those for current OUD therapeutics overall. Anti-opioid vaccines were endorsed as helpful potential additions to current OUD therapeutic approaches, particularly for voluntary use in the later stages of clinical progression." @default.
- W4230147765 created "2022-05-11" @default.
- W4230147765 creator A5035228866 @default.
- W4230147765 creator A5037576909 @default.
- W4230147765 creator A5077505426 @default.
- W4230147765 creator A5078458956 @default.
- W4230147765 date "2021-01-21" @default.
- W4230147765 modified "2023-09-26" @default.
- W4230147765 title "Pharmacy Stakeholder Reports on Ethical and Logistical Considerations in Anti-Opioid Vaccine Development" @default.
- W4230147765 doi "https://doi.org/10.21203/rs.3.rs-38314/v2" @default.
- W4230147765 hasPublicationYear "2021" @default.
- W4230147765 type Work @default.
- W4230147765 citedByCount "0" @default.
- W4230147765 crossrefType "posted-content" @default.
- W4230147765 hasAuthorship W4230147765A5035228866 @default.
- W4230147765 hasAuthorship W4230147765A5037576909 @default.
- W4230147765 hasAuthorship W4230147765A5077505426 @default.
- W4230147765 hasAuthorship W4230147765A5078458956 @default.
- W4230147765 hasBestOaLocation W42301477651 @default.
- W4230147765 hasConcept C104863432 @default.
- W4230147765 hasConcept C118552586 @default.
- W4230147765 hasConcept C126322002 @default.
- W4230147765 hasConcept C144024400 @default.
- W4230147765 hasConcept C144133560 @default.
- W4230147765 hasConcept C15744967 @default.
- W4230147765 hasConcept C162853370 @default.
- W4230147765 hasConcept C170493617 @default.
- W4230147765 hasConcept C17744445 @default.
- W4230147765 hasConcept C201305675 @default.
- W4230147765 hasConcept C27415008 @default.
- W4230147765 hasConcept C2778949969 @default.
- W4230147765 hasConcept C2779418921 @default.
- W4230147765 hasConcept C2779903281 @default.
- W4230147765 hasConcept C2781063702 @default.
- W4230147765 hasConcept C36289849 @default.
- W4230147765 hasConcept C39549134 @default.
- W4230147765 hasConcept C512399662 @default.
- W4230147765 hasConcept C56995899 @default.
- W4230147765 hasConcept C71924100 @default.
- W4230147765 hasConceptScore W4230147765C104863432 @default.
- W4230147765 hasConceptScore W4230147765C118552586 @default.
- W4230147765 hasConceptScore W4230147765C126322002 @default.
- W4230147765 hasConceptScore W4230147765C144024400 @default.
- W4230147765 hasConceptScore W4230147765C144133560 @default.
- W4230147765 hasConceptScore W4230147765C15744967 @default.
- W4230147765 hasConceptScore W4230147765C162853370 @default.
- W4230147765 hasConceptScore W4230147765C170493617 @default.
- W4230147765 hasConceptScore W4230147765C17744445 @default.
- W4230147765 hasConceptScore W4230147765C201305675 @default.
- W4230147765 hasConceptScore W4230147765C27415008 @default.
- W4230147765 hasConceptScore W4230147765C2778949969 @default.
- W4230147765 hasConceptScore W4230147765C2779418921 @default.
- W4230147765 hasConceptScore W4230147765C2779903281 @default.
- W4230147765 hasConceptScore W4230147765C2781063702 @default.
- W4230147765 hasConceptScore W4230147765C36289849 @default.
- W4230147765 hasConceptScore W4230147765C39549134 @default.
- W4230147765 hasConceptScore W4230147765C512399662 @default.
- W4230147765 hasConceptScore W4230147765C56995899 @default.
- W4230147765 hasConceptScore W4230147765C71924100 @default.
- W4230147765 hasLocation W42301477651 @default.
- W4230147765 hasLocation W42301477652 @default.
- W4230147765 hasOpenAccess W4230147765 @default.
- W4230147765 hasPrimaryLocation W42301477651 @default.
- W4230147765 hasRelatedWork W2018461713 @default.
- W4230147765 hasRelatedWork W2907334930 @default.
- W4230147765 hasRelatedWork W2944736729 @default.
- W4230147765 hasRelatedWork W2964669656 @default.
- W4230147765 hasRelatedWork W2964719689 @default.
- W4230147765 hasRelatedWork W3037229384 @default.
- W4230147765 hasRelatedWork W3189342242 @default.
- W4230147765 hasRelatedWork W3189436618 @default.
- W4230147765 hasRelatedWork W4283026247 @default.
- W4230147765 hasRelatedWork W4285679284 @default.
- W4230147765 isParatext "false" @default.
- W4230147765 isRetracted "false" @default.
- W4230147765 workType "article" @default.