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• W4230163313 abstract "Contrast-induced nephropathy (CIN) is a life-threatening complication after primary percutaneous coronary intervention (p-PCI). Oxidative stress and inflammation may play an important role in the development of CIN. We aimed to assess the relationship between total oxidant status, total antioxidant capacity, high-sensitivity C-reactive protein (hs-CRP), gamma-glutamyltransferase and uric acid (UA) in the development of CIN in patients presenting with ST-elevation myocardial infarction (STEMI). This prospective cohort study consisted of 341 patients with STEMI. Patients were divided into two groups: those with and those without CIN. Predictors of CIN were determined by multivariate regression analyses. Multivariate regression analysis showed that initial glucose level, contrast media volume/glomerular filtration ratio (eGFR) ratio, hs-CRP, UA and oxidative status index were associated with the development of CIN in patients with STEMI. The main finding of this study is that increased oxidative stress and inflammation parameters were associated with the development of CIN in patients with STEMI. Other independent predictors of CIN were contrast media volume/eGFR ratio, initial glucose level, UA and hs-CRP. A nefropatia induzida por contraste (NIC) é uma complicação crítica após intervenção coronária percutânea primária (ICP-p). O stress oxidativo e a inflamação podem ter um papel importante no desenvolvimento da NIC. Avaliar a associação entre o estado oxidante total (EOT), a capacidade total (COT), a proteína C-reativa de alta sensibilidade (PCR-as), a gama glutamiltransferase (GGT) e o ácido úrico (AU) no desenvolvimento de doentes com NIC que se apresentam com STEMI. Este estudo de coorte prospetivo incluiu 341 doentes com enfarte do miocárdio com elevação do segmento ST (STEMI). Os doentes foram divididos em dois grupos: os portadores e os não portadores de NIC. Os valores preditivos de NIC foram determinados por análises de regressão multivariada. A análise de regressão multivariada demonstrou que o nível inicial de glicose, o volume dos meios de contraste/taxa de filtração glomerular estimada (TFGe), a PCR-as e o índice do estado oxidativo foram associados ao desenvolvimento da NIC em doentes com STEMI. O aumento do stress oxidativo e dos parâmetros inflamatórios estão associados ao desenvolvimento da NIC em doentes com STEMI. Outros fatores preditivos independentes da NIC foram o volume dos meios de contraste/TFG, o nível daglicemia inicial, o AU e a PCR-as." @default.
• W4230163313 created "2022-05-11" @default.
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• W4230163313 date "2021-07-01" @default.
• W4230163313 modified "2023-10-16" @default.
• W4230163313 title "Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction" @default.
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• W4230163313 doi "https://doi.org/10.1016/j.repce.2021.07.018" @default.
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