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• W4230238756 abstract "In raising the issue regarding the potential immunogenetic factors that may protect Hispanics, Dr. Lenworth N. Johnson correctly points out that previous reports suggest an increased association of HLA-DRβ1∗04 allele with the development of giant cell arteritis (GCA).1Weyand C.M. Hicok K.C. Hunder G.G. Goronzy J.J. The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule.J Clin Invest. 1992; 990: 2355-2361Crossref Scopus (210) Google Scholar Moreover, there seem to be no significant difference in the distribution of HLA-DRβ1∗04 among Caucasians and Hispanics. Because none of our Hispanic patients developed biopsy-proven GCA (P < 0.001), we suggested that unknown factors may protect Hispanics from this arteritis. It should be noted that HLA-DRβ1∗04 was only found in 60% of the 42 patients with biopsy-proven GCA.1Weyand C.M. Hicok K.C. Hunder G.G. Goronzy J.J. The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule.J Clin Invest. 1992; 990: 2355-2361Crossref Scopus (210) Google Scholar Such findings suggest that other genetic polymorphisms could play a role in the pathogenesis of GCA. These include intercellular adhesion molecule-1, interleukin-1 receptor antagonist, and tumor necrosis factor.2Gonzalez-Gay M.A. Genetic epidemiology. Giant cell arteritis and polymyalgia rheumatica.Arthritis Res. 2001; 3: 154-157Crossref PubMed Scopus (67) Google Scholar There may also be as yet unknown genetic associations that are protective within the Hispanic population, similar to those protective genetic associations described in Asian populations with Vogt-Koyanagi-Harada syndrome. Kim et al,3Kim M.H. Seong M.C. Kwak N.H. et al.Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans.Am J Ophthalmol. 2000; 129: 173-177Abstract Full Text Full Text PDF PubMed Scopus (67) Google Scholar found that several subtype proteins, including HLA-DRβ1∗08, -DRβ1∗13, and -DRβ1∗14, were underexpressed in Korean patients, and a similar negative association has been found in Japanese patients with HLA-DQβ1∗0604.4Islam S.M. Numaga J. Fujino Y. et al.HLA class II genes in Vogt-Koyanagi-Harada disease.Invest Ophthalmol Vis Sci. 1994; 35: 3890-3896PubMed Google Scholar As we suggested, further studies are required to evaluate those factors and others." @default.
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• W4230238756 date "2002-02-01" @default.
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• W4230238756 doi "https://doi.org/10.1016/s0161-6420(01)01040-5" @default.
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