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- W4230256426 abstract "Abstract Salmonella enterica serovar Gallinarum biovar Pullorum (bvP) and biovar Gallinarum (bvG) are the etiological agents of pullorum disease (PD) and fowl typhoid (FT) respectively, which cause huge economic losses to poultry industry especially in developing countries including India. Vaccination and biosecurity measures are currently being employed to control and reduce the S . Gallinarum infections. High endemicity, poor implementation of hygiene and lack of effective vaccines pose challenges in prevention and control of disease in intensively maintained poultry flocks. Comparative genome analysis unravels similarities and dissimilarities thus facilitating identification of genomic features that aids in pathogenesis, niche adaptation and in tracing of evolutionary history. The present investigation was carried out to assess the genotypic differences amongst S. enterica serovar Gallinarum strains including Indian strain S. Gallinarum Sal40 VTCCBAA614 with a focus on identification of candidate virulence factors. The comparative genome analysis revealed an open pan-genome consisting of 5091 coding sequence (CDS) with 3270 CDS belonging to core-genome, 1254 CDS to dispensable genome and strain specific genes i.e. singletons ranging from 3 to 102 amongst the analyzed strains. Moreover, the investigated strains exhibited diversity in genomic features such as genomic islands, prophage regions, toxin-antitoxin cassettes, and acquired antimicrobial resistance genes. The identified genetic differences among the S. enterica serovar Gallinarum strains could be used for bacterial typing, design of rapid and reliable diagnostics, structure based inhibitor development and vaccine design for effective infection control as well as eradication and will also form basis for future experimental investigations." @default.
- W4230256426 created "2022-05-11" @default.
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- W4230256426 date "2020-11-24" @default.
- W4230256426 modified "2023-10-16" @default.
- W4230256426 title "Comparative genome analysis of Salmonella enterica serovar Gallinarum biovars Pullorum and Gallinarum decodes strain specific genes" @default.
- W4230256426 doi "https://doi.org/10.21203/rs.3.rs-112825/v1" @default.
- W4230256426 hasPublicationYear "2020" @default.
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