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• W4230257524 abstract "<ns3:p>Accessory gland proteins (ACPs) are important reproductive proteins produced by the male accessory glands (MAGs) of most insect species. These proteins are essential for male insect fertility, and are transferred alongside semen to females during copulation. ACPs are poorly characterized in <ns3:italic>Glossina</ns3:italic> species (tsetse fly), the principal vector of the parasite that causes life-threatening Human African Trypanosomiasis and Animal trypanosomiasis in endemic regions in Africa. The tsetse fly has a peculiar reproductive cycle because of the absence of oviposition. Females mate once and store sperm in a spermathecal, and produce a single fully developed larva at a time that pupates within minutes of exiting their uterus. This slow reproductive cycle, compared to other insects, significantly restricts reproduction to only 3 to 6 larvae per female lifespan. This unique reproductive cycle is an attractive vector control strategy entry point. We exploit comparative genomics approaches to explore the diversity of ACPs in the recently available whole genome sequence data from five tsetse fly species (<ns3:italic>Glossina morsitans, G. austeni, G. brevipalpis, G. pallidipes </ns3:italic>and <ns3:italic>G. fuscipes</ns3:italic>). We used previously described ACPs in <ns3:italic>Drosophila melanogaster</ns3:italic> and <ns3:italic>Anopheles gambiae</ns3:italic> as reference sequences. We identified 36, 27, 31, 29 and 33 diverse ACP orthologous genes in <ns3:italic>G. austeni, G. brevipalpis, G. fuscipes, G. pallidipes </ns3:italic>and<ns3:italic> G. morsitans</ns3:italic> genomes respectively, which we classified into 21 functional classes. Our findings provide genetic evidence of MAG proteins in five recently sequenced <ns3:italic>Glossina </ns3:italic>genomes. It provides new avenues for molecular studies that evaluate potential field control strategies of these important vectors of human and animal disease.</ns3:p>" @default.
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• W4230257524 date "2017-08-30" @default.
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• W4230257524 title "Comparative genomics identifies male accessory gland proteins in five Glossina species" @default.
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• W4230257524 doi "https://doi.org/10.12688/wellcomeopenres.12445.1" @default.
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